Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Analisis Sistem Photovoltaic Beban Arus Searah Terhubung Jala PLN dengan Penyearah Terkendali
Photovoltaic (PV) systems can be connected to the utility grid to ensure the reliability and continuity of the electrical energy supply. Although the output of the PV modules and many electrical loads are direct current (DC), most grid connected PV ...
Winasis Winasis, Muhammad Syaiful Aliim
doaj +1 more source
Free-piston Stirling hydraulic engine and drive system for automobiles [PDF]
The calculated fuel economy for an automotive free piston Stirling hydraulic engine and drive system using a pneumatic accumulator with the fuel economy of both a conventional 1980 spark ignition engine in an X body class vehicle and the estimated fuel ...
Beremand, D. G. +3 more
core +1 more source
Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang +9 more
wiley +1 more source
Ignitability test method and apparatus [PDF]
An apparatus for testing ignitability of an initiator includes a body with a central cavity, initiator holder for holding the initiator over the central cavity of the body, an ignition material holder disposed in the central cavity of the body and a ...
Bailey, James W. +2 more
core +1 more source
Evaluation of WRF-Sfire Performance with Field Observations from the FireFlux experiment [PDF]
This study uses in-situ measurements collected during the FireFlux field experiment to evaluate and improve the performance of coupled atmosphere-fire model WRF-Sfire.
Beezley, Jonathan D. +5 more
core +3 more sources
BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao +9 more
wiley +1 more source
Effort to increase an engine performance using electrical ignition system for motor vehicle
Increasing engine performances using electrical ignition system on motor vehicle. In accordance with the development oftechnology, improvisation of automotive is created in order to increase the performance of engine.
I Wayan Bandem Adnyana
doaj
The influence of strong ignition sources on the explosion and decomposition limits of gases
Explosion and decomposition limits of flammable and chemically unstable gases were determined experimentally in a closed autoclave with an ignition energy higher than the standard 10 J a 20 J.
Enis Askar, Volkmar Schroeder
doaj +1 more source
Quantifying "Cliffs" in Design Space
This paper studies the regions of parameter space of engineering design in which performance is sensitive to design parameters. Some of these parameters (for example, the dimensions and compositions of components) constitute the design, but others are ...
Katz, J. I.
core +1 more source

