Results 151 to 160 of about 69,534 (266)

Splendidly Ignorant and Uncertain. [PDF]

J Card Fail Intersect
Katz JN, Reza N.
europepmc   +1 more source

A Unifying Thermodynamic Model for Phase Separation and Aging of Biopolymers

Advanced Science, EarlyView.
Phase separation and aging of intrinsically disordered proteins are placed in a unifying framework. A thermodynamically consistent time‐dependent version of associating‐polymer theory shows how the processes are intricately coupled. Assuming aging to occur through interacting sites resulting from reversible conformational transitions, the model ...
Jasper J. Michels, Joana Caria, Edward A. Lemke   +2 more
wiley   +1 more source

How the brain structures the boundaries of psychiatric discourse. [PDF]

Front Psychol
Gauld C, Micoulaud-Franchi JA.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

A survey about laughter upon viewing functional seizures. [PDF]

Front Neurol
Koubeissi MZ, Jaafar N, Saouda C, Eid A, LaFrance WC, Öztosun G, Aziz HS, Khan MT, Khan FA, Syed AU, Khalil A, Gürses C, Syed TU.   +12 more
europepmc   +1 more source

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

Advanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan, James R. M. Black, Carlos Martínez‐Ruiz, Kristiana Grigoriadis, Jasmin Fisher, Nicholas McGranahan   +5 more
wiley   +1 more source

Navigating Medicine's Uncertainties. [PDF]

Cureus
Frost DW.
europepmc   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Beyond recognition: Refining the assessment of public knowledge and risk perception in dementia prevention. [PDF]

J Prev Alzheimers Dis
Xie Z, Su J, Liao T.
europepmc   +1 more source

Revealing the Giant Electromechanical Effects in Yttria‐Stabilized Zirconia Single Crystal

Advanced Science, EarlyView.
Giant electromechanical responses are uncovered in yttria‐stabilized zirconia single crystal (SC‐YSZ), exhibiting pronounced orientation dependence. The giant electrostriction and piezoelectricity are directly correlated with the long‐range transport kinetics of oxygen vacancies.
Zhuwu Yi, Kai Pan, Chaoming Hu, Luocheng Liao, Zhijian He, Ziwei Guo, Yibao Wu, Changxing Zhao, Shuhong Xie   +8 more
wiley   +1 more source