Results 11 to 20 of about 756 (106)

A phase 1 evaluation of inhaled oxytocin: Physiologically-based pharmacokinetic model informed dosing of a novel heat-stable oxytocin delivery system. [PDF]

Br J Clin Pharmacol
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Lambert P, Kirkpatrick CMJ, Marriott R, Chaudhuri SR, Polidori D, Remmerie B, McIntosh MP.   +6 more
europepmc   +2 more sources

Genetic Analysis of Invasive Rats From the Hahajima Islands in the Ogasawara Islands. [PDF]

Ecol Evol
The black rat (Rattus tanezumi) inhabits Katsuodorijima Island in the Hahajima Islands. Furthermore, unique haplotypes were observed in Meijima and Mukohjima in the D‐loop analysis. ABSTRACT Based on mitochondrial DNA (mtDNA) sequences, we concluded that the Hahajima Islands are largely inhabited by Rattus norvegicus (brown rat), except for ...
Katayama M, Kawakami K, Onuma M, Kawai YK.   +3 more
europepmc   +2 more sources

Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions.
Marcos-Perez D, Cruces-Salguero S, Saeteros M, Molina RG, Alcantud-Córcoles R, Alonso-Bouzon C, Vergara I, Sanabria SJ, Rodriguez-Mañas L, Abizanda P, Matheu A.   +10 more
europepmc   +2 more sources

Tracing Taonga Trajectories: A Methodological Framework for Indigenous Heritage Mapping. [PDF]

J R Soc N Z
Rangitāhua is a tupuna to Ngāti Kuri and represents the iwi's geographic and ancestral connection to the Pacific. Despite this millennium‐long ancestral tie, Ngāti Kuri's access to Rangitāhua has been severed for two centuries. Meanwhile, many European expeditions visited the islands, extracting and distributing natural history taonga across ...
Ferrari de Aquino Klemm M, Milne C, Brown I, Ringham S, Nelson WA.   +4 more
europepmc   +2 more sources

The Role of Machine-readable Portrayal Catalogue for Displaying New S-100 Format Data in ECDIS [PDF]

TransNav
The purpose of this article is to familiarize users of Electronic Nautical Charts (ENC) with one of the key components of the new IHO S-100 format, which is an automatic set of data visualization rules called the Portrayal Catalogue (PC).
Tymoteusz Tomczuk
doaj   +1 more source

Sensory Characterization of Cookies With Sugar Replacement by Sweeteners Using the Check-All-That-Apply (CATA) Method. [PDF]

J Food Sci
ABSTRACT This study investigated the sensory effects of replacing sucrose with blends of xylitol, monk fruit extract (Siraitia grosvenorii, rich in mogrosides), and thaumatin in 16 prototype cookie formulations. A consumer‐based check‐all‐that‐apply (CATA) test (n = 62 regular cookie consumers) was conducted, followed by Cochran's Q test, principal ...
Lima IHO, Brito NLH, Cardoso FAR, Fuchs RHB.   +3 more
europepmc   +2 more sources

Production Challenges in the Transition from S-57 to S 101 [PDF]

TransNav
This paper examines the transition from S-57 to S-101 in the context of implementing the S-100 framework, with particular attention to dual-fuel ENC production and its broader operational implications.
Mykola Tsymbal, Vladyslav Konon, Nataliia Konon, Oleksandr Pipchenko, Valerii Shevchenko   +4 more
doaj   +1 more source

Towards an Open Platform for S-100 Service Experimentation: A Proof-of-Concept S-124 Navigational Warnings Plugin for OpenCPN [PDF]

TransNav
The transition from the S-57 electronic navigational charting environment towards the IHO S-100 framework is introducing a growing family of interoperable maritime data products and services.
Pedro Marino Laso, Hasan Ahmad
doaj   +1 more source

The New Electronic Chart Product Specification S-101: An Overview [PDF]

TransNav, 2011
The development of S-101 represents a major step forward in product specifications for Electronic Navigational Charts (ENC). Based on the IHO geospatial framework standard S-100, S-101 will become the eventual replacement to S-57 ENCs.
Julia Powell
doaj  

The Transition of the Maritime and Port Industry Toward Automation: A Focus on Maritime Autonomous Surface Ships (MASS) [PDF]

TransNav
The maritime and port industry is undergoing a profound technological transformation, driven by the need to improve operational efficiency, safety and the protection of both the maritime and land environment.
Andrzej Bak
doaj   +1 more source