Results 111 to 120 of about 62,434 (243)

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

open access: yesAngewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog   +5 more
wiley   +2 more sources

Lymphatic Abnormalities in Noonan Syndrome Extend Beyond Clinically Apparent Disease

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Lymphatic disease represents a well‐described manifestation of Noonan syndrome (NS), yet the full phenotypic spectrum remains incompletely characterized, especially in asymptomatic individuals. We conducted a cross‐sectional study including 10 individuals with NS (four with peripheral lymphedema and six without) and 10 age‐ and sex‐matched ...
Inger Norlyk Sheyanth   +7 more
wiley   +1 more source

Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation

open access: yesAngewandte Chemie, EarlyView.
Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen   +17 more
wiley   +2 more sources

Optimized inverse kinematics solutions for a 6-DOF robot. [PDF]

open access: yesSci Rep
Bayoume MO   +3 more
europepmc   +1 more source

A modified D‐galactose‐induced aging rat model with low‐dose intraperitoneal ozone: Redox, functional, and skin outcomes

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem   +6 more
wiley   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

open access: yesAnnals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos   +46 more
wiley   +1 more source

[The Context-Sensitive Positive Health Questionnaire (CPHQ<sub>2.0</sub>), a broad health questionnaire based on a combination of the Capability Approach and the Positive Health concept]. [PDF]

open access: yesTSG
Bloemen-van Gurp EJ   +8 more
europepmc   +1 more source

A new Patient‐Reported Outcome Scale to assess autoimmune Encephalitis: PROSE

open access: yesAnnals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AIE) has long‐lasting effects. Generic clinical assessment‐scales insufficiently capture disease‐specific sequelae. Patient‐reported outcome measures (PROMs) assess outcomes important to patients, ensuring relevance in the clinic and trials.
Juliette Brenner   +24 more
wiley   +1 more source

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