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2006
IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Jill M. Kramer +3 more
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IL-17A and its receptor are the founding members of a recently described cytokine family, with unique sequences and functions in the immune system and elsewhere. Consisting of six ligands (IL-17A-F) and five receptors (IL-17RA-IL-17RE) in mammals, these molecules have distinct primary amino acid structures with only minimal homology to other cytokine ...
Jill M. Kramer +3 more
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IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential
Clinical Science, 2012IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in host defence against bacterial and fungal infections, as well as in the pathogenesis of autoimmune diseases. The present review focuses on current knowledge of the regulation, functional mechanisms and targeting strategies of IL-17 in the context of ...
Shu Zhu, Youcun Qian
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The role of IL-17 and IL-17 receptor inhibitors in the management of generalized pustular psoriasis
Drugs of Today, 2019Generalized pustular psoriasis (GPP) is a severe psoriasis form that can be refractory to several systemic treatments. The role of interleukin (IL)-17/ T-helper 17 (Th17) axis inhibitors in the therapy of GPP is not fully established. The objective of this paper is to summarize the existing information on the efficacy and safety of secukinumab ...
Kerasia Maria Plachouri +2 more
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The Impact of IL-17 in Atherosclerosis
Current Medicinal Chemistry, 2017Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel.
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Stromal support from IL-17 [PDF]
Nature Reviews Immunology, 2019 During inflammation, IL-17 rewires metabolic processes in lymph node fibroblastic reticular cells, thereby supporting their survival and population expansion.
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IL-17 inhibitors for moderate-to-severe psoriasis
Seminars in Cutaneous Medicine and Surgery, 2018The role of the Th17/interleukin (IL)-23 pathway has been well elucidated in psoriasis. The IL-17 family includes 6 cytokines: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F. Two monoclonal antibodies targeting IL-17A (secukinumab, ixekizumab) and one antibody against the IL-17 receptor (brodalumab) have been approved for the treatment of moderate ...
Dario Kivelevitch +5 more
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Role of IL-17 in asthma pathogenesis and its implications for the clinic
Expert Review of Respiratory Medicine, 2019Introduction: Asthma is a respiratory disorder typically characterized by T-helper type 2 (Th2) inflammation that is mediated by cytokines, including IL-4, IL-5, and IL-13.
R. Ramakrishnan, S. Al Heialy, Q. Hamid
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Role of IL-17 and IL-17 Family Cytokines on Tumor Development
2012Anticancer immune responses restrain tumor progression, but persistent immune activation can induce chronic inflammation that contributes to tumor development. The IL-17 family of cytokines comprises six family members (IL-17A to IL-17F) that all contribute to tissue inflammation.
Frédérique Végran +2 more
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IL-17 and intestinal tumorigenesis
Drug Discovery Today: Disease Mechanisms, 2011IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL-17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial.
Wook-Jin Chae, Alfred L. M. Bothwell
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Science, 2011
Human genetic mutations point to a cytokine as critical for fighting a fungal infection.
Margarita Dominguez-Villar +1 more
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Human genetic mutations point to a cytokine as critical for fighting a fungal infection.
Margarita Dominguez-Villar +1 more
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