Results 141 to 150 of about 191,017 (312)

Analysis of C4 Concentrations to Predict Impact of Patient‐Reported Diarrhea Associated With the Ileal Bile Acid Transporter Inhibitor Linerixibat

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 596-605, March 2025.
ABSTRACT Linerixibat, an ileal bile acid transporter (IBAT) inhibitor, is being evaluated for the treatment of pruritus in primary biliary cholangitis (PBC). Diarrhea is commonly reported with this drug class as IBAT inhibition redirects bile acids (BA) to the colon.
Fernando Carreño, Rashmi Mehta, Andrea Ribeiro de Souza, Jon Collins, Brandon Swift   +4 more
wiley   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Terminal Ileum [PDF]

, 2020
openaire   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Intestinal Web in Jejunum and Ileum among Children: A series of 11 cases

Pakistan Journal of Medical Research
Objective: Web in the small intestine of children is not a commonly encountered entity. Due to partial obstruction, patients may present with varied symptoms and at different ages.
Naveed Haider, Zeeshan Ahmad , Zulfiqar Ahmed , Muhammad Arslan Qureshi, Ibrar Khan, Mansour Mehmood, Naeem Liaqat, Asif Iqbal, Muhammad Imran , Ferheen Shahbaz   +9 more
doaj   +2 more sources

Enterogenous Cysts of Ileum [PDF]

Archives of Disease in Childhood, 1947
openaire   +2 more sources

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

Complete closure of an ileal perforation during enteroscopy using a novel through-the-scope twin clip. [PDF]

Endoscopy
Zhou F, Li W, Peng C, Zheng R, Ding X.
europepmc   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Intestinal Ultrasound for Monitoring Postoperative Crohn's Disease: A Review and Visual Atlas. [PDF]

Inflamm Bowel Dis
Gu P, Karime C, Fleshner P, Falloon K, Qazi T, Ernest-Suarez K, Pabla B, St-Pierre J, Melmed GY, Damas OM, Huynh HQ, Lu C, Kellar A, Intestinal Ultrasound Group of the United States and Canada (iUSCAN) .   +13 more
europepmc   +1 more source