Results 231 to 240 of about 154,630 (309)

Therapeutic Balloon‐Assisted Enteroscopy: Recent Advances in the Management of Small Bowel Diseases

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Balloon‐assisted enteroscopy (BAE) has substantially advanced small bowel disease management. This review summarizes recent therapeutic BAE advances, focusing on three major indications: small bowel vascular lesions, hereditary polyposis syndromes, and Crohn's disease (CD).
Manabu Nagayama, Tsubasa Kinoshita, Hiroyuki Kawaguchi, Toshihiro Fujinuma, Sawako Fujikura, Hiroki Hayashi, Tomoko Tamaru, Hirotsugu Sakamoto, Tomonori Yano   +8 more
wiley   +1 more source

Chronic Enteropathy Associated With SLCO2A1 Gene Mutation; Initially Misdiagnosed as Fibrostenosing Crohn's Disease. [PDF]

ACG Case Rep J
Gessessew H, Qin D, Sharif N, Gandiga P, Iskandar H.   +4 more
europepmc   +1 more source

Mānuka Honey and Leaf Bioactives: A Review of Taonga Natural Products From Leptospermum scoparium

New Zealand Journal of Botany, Volume 64, Issue 4, December 2026.
This comprehensive review of mānuka examines its cultural significance, botany, distinct genetics and unique phytochemistry. It highlights mānuka honey, enriched with antibacterial methylglyoxal derived from nectar dihydroxyacetone, and details markers used to combat honey fraud.
John W. van Klink, Suzanne M. Scheele, Nigel B. Perry   +2 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Reactivation of <i>Cytomegalovirus</i> in Colonic Tuberculosis in an Immunocompetent Patient. [PDF]

Case Rep Infect Dis
Wang A, Ji S, Semon S, Waldman S, Nguyen MH.   +4 more
europepmc   +1 more source

Metformin Use Is Associated With Better Cognitive Performance in Older Adults With Type 2 Diabetes: Exploratory Analysis of Vitamin B12 and Methylmalonic Acid Pathways in NHANES 2011–2014

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11808-11820, December 2026.
ABSTRACT Aims Metformin, the first‐line treatment for Type 2 diabetes mellitus (T2DM), may be neuroprotective but also lowers serum vitamin B12 by ~19%, raising concern that B12 depletion could offset this benefit. We used modern exploratory causal mediation methods in a nationally representative sample to test whether vitamin B12 and methylmalonic ...
Danial Fotros, Hanieh Sakhdari, Andrew C. Shin   +2 more
wiley   +1 more source

Effects of Ellagic Acid on Gut Microbiota and Tryptophan Metabolism in Paraquat-Challenged Piglets Subjected to Ampicillin-Induced Microbiota Perturbation. [PDF]

Antioxidants (Basel)
Deng Y, Wang C, Meng Y, Yin Y, Wang J, Ye Q.   +5 more
europepmc   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

Histopathology, Volume 89, Issue 6, Page 1031-1041, December 2026.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin, Wenjian Cen, Qin Yan, Yangshan Chen, Chaoyun Huang, Yanfeng Feng, Neng Jiang   +6 more
wiley   +1 more source

Low-Dose Glyphosate Exposure Alters the Enteric Tachykinin System in the Porcine Small Intestine. [PDF]

Int J Mol Sci
Walczak-Mośny Z, Chmielewska-Krzesińska M, Jana B, Palus K.   +3 more
europepmc   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, Volume 179, Issue 4, Page 594-608, December 2026.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source