Results 291 to 300 of about 194,648 (336)

Intestinal Dysmotility and Associated Disorders in Intestinal Muscle of Methylglyoxal‐Treated Mice

open access: yesNeurogastroenterology &Motility, EarlyView.
In patients undergoing long‐term peritoneal dialysis, intestinal transit capacity is often impaired, though the underlying mechanism remains unclear. Using a mouse model, we identified inflammation and impairment of interstitial cells of Cajal (ICC) in intestinal smooth muscle as potential contributors to this reduced transit capacity.
Yuki Yamakawa   +2 more
wiley   +1 more source

A case report of an ileo-appendicular knotting causing strangulated small bowel obstruction. [PDF]

open access: yesInt J Surg Case Rep
Plante PR   +5 more
europepmc   +1 more source

Pathology Seen in Myenteric Plexus in Two Subjects With Waardenburg Syndrome

open access: yesNeurogastroenterology &Motility, EarlyView.
Ganglion cells immunohistochemically labeled with pan‐neuronal marker HuC/D in sections from ileum. Note the different number of stained cells in the myenteric plexus. A, control subject, B, patient with SOX10 mutation (hypoganglionosis) C, patient with EDN3 mutation (aganlionosis). Both patients diagnosed with Waardenburg syndrome type 4 including gut
Björn Ersson   +3 more
wiley   +1 more source

Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross‐Over Study in Healthy Volunteers

open access: yesNeurogastroenterology &Motility, EarlyView.
Alterations in whole gut transit time (WGTT) significantly impact microbiome composition and bile acid metabolism. Using senna and loperamide, we show that WGTT changes influence bacterial diversity, bile acid profiles, and fibroblast growth factor 19, with effects reversing after 16 days—highlighting the dynamic gut‐microbiome‐bile acid interplay ...
Evette B. M. Hillman   +11 more
wiley   +1 more source

A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease

open access: yesNeurogastroenterology &Motility, EarlyView.
Incubation of esophageal epithelial cells with a weakly acidic (pH 5) bile salt (deoxycholic acid) induces translocation of HMGB1 from the nucleus to the cytosol, and its subsequent release from the cell. This process can be ameliorated by pre‐treatment with the antioxidant, curcumin.
Tom Leech   +4 more
wiley   +1 more source

Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion. [PDF]

open access: yesBMC Med
Wang F   +11 more
europepmc   +1 more source

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