Results 61 to 70 of about 23,955 (209)

Compact Tabletop Magnetic Resonance Elastography for Mapping Soft Tissue Viscoelasticity

Advanced Science, EarlyView.
This work introduces a compact, low‐cost tabletop magnetic resonance elastography platform for high‐resolution viscoelastic mapping in soft‐tissue specimens. Using this method in human colorectal liver metastases, we demonstrate fully automated biomechanical profiling of treatment response and show that heterogeneity‐based metrics outperform ...
Weijie Zhao, Lisa‐Marie Skrip, Heiko Tzschätzsch, Tom Meyer, Hossein S. Aghamiry, Alexander Arnold, Lene Änne Böhne, Jakob Jordan, Oliver Boehm, Agnes K. Boehm, Steffen Görner, Jakob Schattenfroh, Yanglei Wu, Pedro Augusto Dantas de Moraes, Johann Pratschke, Jürgen Braun, Igor M. Sauer, Jing Guo, Ingolf Sack, Karl H. Hillebrandt   +19 more
wiley   +1 more source

On the ill-posed problem for the Poisson equation

Қарағанды университетінің хабаршысы. Математика сериясы, 2018
A boundary value problem in a two - dimensional rectangular region for the Poisson equation is studied in the paper. The original ill - posed boundary value problem is transformed to the optimal control problem.
M.T. Jenaliyev, M.M. Amangaliyeva, K.B. Imanberdiyev   +2 more
doaj   +1 more source

Beyond Percolation: Graphene‐Enabled Network Reinforcement Enhances Thermal Transport in Paraffin Phase‐Change Composites

Advanced Science, EarlyView.
Expanded‐graphite/graphene‐nanoplatelet hybrids deliver a near‐order‐of‐magnitude thermal‐conductivity enhancement in paraffin phase‐change materials. A microCT‐informed 3D modeling framework resolves the percolating EG backbone and captures sub‐voxel GNP enrichment, quantitatively linking microstructure to heat flow and revealing a graphene‐enabled ...
Thomas Hoke, Jackson Hoke, Shucheng Guo, Brittany Chan, Xi Chen   +4 more
wiley   +1 more source

On rules for stopping the conjugate gradient type methods in ill‐posed problems

Mathematical Modelling and Analysis, 2007
We consider stopping rules in conjugate gradient type iteration methods for solving linear ill‐posed problems with noisy data. The noise level may be known exactly or approximately or be unknown. We propose several new stopping rules, mostly for the case
Uno Hämarik, Reimo Palm
doaj   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

DETERMINATION OF SELECTED PARAMETERS IN A 1D OPEN CHANNEL FLOW MODEL

TASK Quarterly, 2007
Determination of the model’s parameters is an important stage of mathematical models’ application. In the case of a free-surface 1D unsteady flow model defined by the de Saint-Venant equations, one of the groups of parameters to be estimated is the set ...
KATARZYNA WEINEROWSKA-BORDS
doaj  

Parameter Choice Strategy That Computes Regularization Parameter before Computing the Regularized Solution

Modelling
The modeling of many problems of practical interest leads to nonlinear ill-posed equations (for example, the parameter identification problem (see the Numerical section)).
Santhosh George, Jidesh Padikkal, Ajil Kunnarath, Ioannis K. Argyros, Samundra Regmi   +4 more
doaj   +1 more source

A modified truncation singular value decomposition method for solving ill-posed problems

Journal of Algorithms & Computational Technology, 2018
A modified truncated singular value decomposition method for solving ill-posed problems is presented in this paper, in which the solution has a slightly different form.
Zhenyu Zhao, Riguang Lin, Zehong Meng, Guoqiang He, Lei You, Yongxiong Zhou   +5 more
doaj   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source