Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
Social determinants of homelessness from childhood to adolescence: protocol for a living systematic review and meta-analysis. [PDF]
BMJ OpenHeerde JA, Olsson CA, Sawyer SM.
europepmc +1 more source
Electrical Control of the Transduction Channels’ Gating Force in Mechanosensory Hair Cells
Advanced Science, EarlyView.The inner ear's hair cells rely on mechanosensitive ion channels to convert vibrations of their hair‐bundle into electrical signals. We show that varying the electrical potential (U) across the sensory epithelium modulates a key determinant of mechanosensitivity—the gating force (FG)—by modulating the gating swing (d), ranging from the size of the ...
Achille Joliot +2 more
wiley +1 more source
Field Testing and Validation of a New Question Set to Measure Housing Status - Fulton County, Georgia, August-September 2023. [PDF]
MMWR Morb Mortal Wkly RepBratcher A +7 more
europepmc +1 more source
Grassroots Challenges to the Effects of Prison Sprawl on Mental Health Services for Incarcerated People [PDF]
, 2018 Short, Stefen R.
core +1 more source
Ecosystem‐Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs)
Advanced Science, EarlyView.Robots exploring natural ecosystems can support monitoring and conservation, but must adopt ecosystem‐centered design to avoid pollution, waste, and damage. This review proposes guidelines for co‐designing ecoresorbable sustainability robots (ESRs), uniting materials, robotics, and ecological contexts in a single framework.
Tülin Yılmaz Nayır +4 more
wiley +1 more source
Bridging the Gap: Implementing Consultation-Liaison Psychiatry for Mental Illness in Unhoused Populations. [PDF]
Fam Community HealthHosseini-Navid SN +3 more
europepmc +1 more source
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Addressing Employment Barriers Among Persons with Homeless Experiences: Implementation Lessons For Advancing Equity From an Electronic-Bicycle-Supported Vocational Rehabilitation Pilot. [PDF]
J Prim Care Community HealthPanadero TJ +5 more
europepmc +1 more source
Advanced Science, EarlyView.Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang +11 more
wiley +1 more source