Results 21 to 30 of about 29,061 (317)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Modelling and Simulation in Engineering, 2020 In many references, both the ill-posed and inverse boundary value problems are solved iteratively. The iterative procedures are based on firstly converting the problem into a well-posed one by assuming the missing boundary values.
Mohammed Hamaidi +3 more
doaj +1 more source
Total Fractional-Order Variation-Based Constraint Image Deblurring Problem
Mathematics, 2023 When deblurring an image, ensuring that the restored intensities are strictly non-negative is crucial. However, current numerical techniques often fail to consistently produce favorable results, leading to negative intensities that contribute to ...
Shahid Saleem +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective The aim of this systematic review was to synthesize the economic impact of rheumatoid arthritis (RA) on households, health systems, and society in low‐ and middle‐income countries (LMICs). Methods Electronic databases such as PubMed, Web of Science, and CINAHL were searched using keywords related to RA and cost of illness.
Tadesse Gebrye +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health (SDoH). Methods We conducted a search for keywords, which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the
Joy Buie +11 more
wiley +1 more source
PROBLEMAS INVERSOS MAL COLOCADOS EM QUÍMICA
Química NovaWhat is an ill-posed inverse problem? The answer to this question is the main objective of the present paper and the pre-requisite to follow the material requires only elementary calculus.
João P. Braga +3 more
doaj +1 more source
Solving ill-posed magnetic inverse problem using a Parameterized Trust-Region Sub-problem
Contributions to Geophysics and Geodesy, 2013 The aim of this paper is to find a plausible and stable solution for the inverse geophysical magnetic problem. Most of the inverse problems in geophysics are considered as ill-posed ones.
Maha ABDELAZEEM Mohamed
doaj +1 more source
On Tikhonov's Method for Ill-Posed Problems [PDF]
Mathematics of Computation, 1974 For Tikhonov’s regularization of ill-posed linear integral equations, numerical accuracy is estimated by a modulus of convergence, for which upper and lower bounds are obtained. Applications are made to the backward heat equation, to harmonic continuation, and to numerical differentiation.
openaire +2 more sources
Arthritis Care &Research, Accepted Article.Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies. To help patients and providers in the decision‐making process, we developed
Anahita Deboo +19 more
wiley +1 more source