Results 191 to 200 of about 554,897 (315)

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

SHORTER trial: protocol for a pragmatic, multicentre, randomised controlled trial of short-duration antibiotic therapy for critically ill patients with sepsis. [PDF]

BMJ Open
Mawson P, Morton M, Walmsley Z, Wafer R, Hancock HC, Mossop H, Al-Ashmori S, Emerson LM, Smith J, Colquhoun G, Wu H, Fernandez-Garcia C, Ternent L, Kumar R, Ogden M, Loraine L, Taylor L, Ndlovu S, Hall P, Gordon AC, Rostron A, McMullan R, Felton T, Walsh T, McAuley DF, Dark P, Simpson AJ, Hellyer TP.   +27 more
europepmc   +1 more source

Estyn policy and procedures for safeguarding [PDF]

, 2009

core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Bridging evidence and practice: implementation science and bundled care strategies for fluid management in critically ill neonates. [PDF]

Front Med (Lausanne)
Pak AC, Neyra JA, Brown JR, Travers CP, Starr MC, Harer MW, Sullivan I, MacKenzie TA, Colicchio TK, Griffin R, Askenazi DJ.   +10 more
europepmc   +1 more source

Disavowing democracy: the silencing project in the South [PDF]

, 2004
O'Brien, Mark
core  

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Korean Society of Nephrology 2025 evidence-based clinical practice guideline for continuous kidney replacement therapy. [PDF]

Kidney Res Clin Pract
Lee J, Kang D, Paek JH, Lee J, An JN, Jeon J, Lee K, Jang HR, Jhee JH, Kim HJ, Rhee H, Lim SY, Yang J, Kim SG, Han SS, Ahn SY, Park S, Lee HK, Cho H, Lee Y, Kim HW, Kim K, Choi M, Kim S.   +23 more
europepmc   +1 more source

Integrated Children’s System: analysing and recording significant harm: using ICS to record the evidence of whether a child is suffering, or likely to suffer, significant harm [PDF]

, 2010

core  

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source