Results 211 to 220 of about 531,444 (314)

Effect of sialidase inhibitors on a plaque community biofilm model. [PDF]

Access Microbiol
Ramalingam C, Ansbro K, Pratten J, Bradshaw D, Stafford GP.   +4 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Complete genome sequence of <i>Paenibacillus</i> sp. PK1-4R (DSM 120655) isolated from the rhizosphere of <i>Brassica napus</i> in Rostock, Germany. [PDF]

Microbiol Resour Announc
Ruciaka PK, Lemfack MC, Bunk B, Spröer C, Piechulla B.   +4 more
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Deciphering Trypanosoma lainsoni kDNA minicircles: insights into genetic diversity, mRNA editing, and molecular diagnosis. [PDF]

Parasite
Aguirre JJ, Floridia-Yapur N, Rusman F, Hodi S, Ponce T, Diaz AG, Greif G, Berná L, Robello C, Diosque P, Tomasini N.   +10 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

P631: Genome screening of newborns: What can we find and what’s next?*

Genetics in Medicine Open
Jorune Balciuniene, Ruby Liu, Jonathan Carmichael, Mauro Longoni, Sucheta Bhatt, Madhuri Hegde   +5 more
doaj   +1 more source

An increased number of heterozygous calls in the AxiomTM Equine Genotyping Array. [PDF]

G3 (Bethesda)
Gmel AI, Pirani A, McInnis L, Neuditschko M.   +3 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

P368: Novel mutation in ZIC3 in a Peruvian family with variable phenotype VACTERL-H association

Genetics in Medicine Open
Giulliana Chávez-Pasco, Jeny Bazalar-Montoya, Cecilia Bonilla Suarez, Krista Bluske, Samuel Strom, Alka Malhotra, Becky Milewski, Erin Thorpe, Ryan Taft, Gioconda Manassero-Morales   +9 more
doaj   +1 more source