Results 1 to 10 of about 41,796 (182)

A recurrent sequencing artifact on Illumina sequencers with two-color fluorescent dye chemistry and its impact on somatic variant detection [PDF]

Abstract Background The sequencing-by-synthesis technology by Illumina, Inc. enables efficient and scalable readouts of mutations from genomic data. To enhance sequencing speed and efficiency, Illumina has shifted from the four-color base calling chemistry of the HiSeq series to a two-color fluorescent dye ...
Beverly J. Fu, Vinayak V Viswanadham, Dominika Maziec, Hu Jin, Peter J. Park   +4 more
openaire   +2 more sources

Transcriptome profiling for precision cancer medicine using shallow nanopore cDNA sequencing

Scientific Reports, 2023
Transcriptome profiling is a mainstay of translational cancer research and is increasingly finding its way into precision oncology. While bulk RNA sequencing (RNA-seq) is widely available, high investment costs and long data return time are limiting ...
Andreas Mock, Melissa Braun, Claudia Scholl, Stefan Fröhling, Cihan Erkut   +4 more
doaj   +1 more source

De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids. [PDF]

PLoS ONE, 2013
Herbal remedies are increasingly being recognised in recent years as alternative medicine for a number of diseases including cancer. Curcuma longa L., commonly known as turmeric is used as a culinary spice in India and in many Asian countries has been ...
Ramasamy S Annadurai, Ramprasad Neethiraj, Vasanthan Jayakumar, Anand C Damodaran, Sudha Narayana Rao, Mohan A V S K Katta, Sreeja Gopinathan, Santosh Prasad Sarma, Vanitha Senthilkumar, Vidya Niranjan, Ashok Gopinath, Raja C Mugasimangalam   +11 more
doaj   +1 more source

Shotgun sequencing to determine corneal infection

American Journal of Ophthalmology Case Reports, 2020
Purpose: To investigate if shotgun-sequencing method could be useful in detailed diagnosis of herpes simplex virus (HSV) infection and compare it with the conventional diagnostic method.
Mohit Parekh, Vito Romano, Antonella Franch, Pia Leon, Federica Birattari, Davide Borroni, Stephen B. Kaye, Diego Ponzin, Sajjad Ahmad, Stefano Ferrari   +9 more
doaj   +1 more source

Aspergillus sydowii: Genome Analysis and Characterization of Two Heterologous Expressed, Non-redundant Xylanases

Frontiers in Microbiology, 2020
A prerequisite for the transition toward a biobased economy is the identification and development of efficient enzymes for the usage of renewable resources as raw material.
Sophie C. Brandt, Bernhard Ellinger, Thuat van Nguyen, Sönke Harder, Hartmut Schlüter, Richard L. Hahnke, Martin Rühl, Wilhelm Schäfer, Martin Gand, Martin Gand   +9 more
doaj   +1 more source

Addressing challenges in the production and analysis of illumina sequencing data

BMC Genomics, 2011
Advances in DNA sequencing technologies have made it possible to generate large amounts of sequence data very rapidly and at substantially lower cost than capillary sequencing.
Kelso Janet, Heyn Patricia, Kircher Martin   +2 more
doaj   +1 more source

Transcriptome of the Australian Mollusc Dicathais orbita Provides Insights into the Biosynthesis of Indoles and Choline Esters

Marine Drugs, 2016
Dicathais orbita is a mollusc of the Muricidae family and is well known for the production of the expensive dye Tyrian purple and its brominated precursors that have anticancer properties, in addition to choline esters with muscle-relaxing properties ...
Abdul Baten, Ajit Kumar Ngangbam, Daniel L. E. Waters, Kirsten Benkendorff   +3 more
doaj   +1 more source

Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties

BMC Genomics, 2012
Background Phyto-remedies for diabetic control are popular among patients with Type II Diabetes mellitus (DM), in addition to other diabetic control measures. A number of plant species are known to possess diabetic control properties.
Annadurai Ramasamy S, Jayakumar Vasanthan, Mugasimangalam Raja C, Katta Mohan AVSK, Anand Sanchita, Gopinathan Sreeja, Sarma Santosh, Fernandes Sunjay, Mullapudi Nandita, Murugesan S, Rao Sudha   +10 more
doaj   +1 more source

3127 The effect of common genetic variants in the oxytocin receptor gene on oxytocin response.

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: Previous studies suggest that genetic variants in the oxytocin receptor (OXTR) may alter oxytocin dose requirement for labor induction and may increase risk for preterm labor and neurodevelopmental disorders.
Manasi Malik, Naiqi Shi, Geraldine Serwald, Grace Y. Lee, Antonina I. Frolova, Céline Galés, Sarah K. England   +6 more
doaj   +1 more source

Human presence impacts fungal diversity of inflated lunar/Mars analog habitat

Microbiome, 2017
Background An inflatable lunar/Mars analog habitat (ILMAH), simulated closed system isolated by HEPA filtration, mimics International Space Station (ISS) conditions and future human habitation on other planets except for the exchange of air between ...
A. Blachowicz, T. Mayer, M. Bashir, T. R. Pieber, P. De León, K. Venkateswaran   +5 more
doaj   +1 more source