Results 41 to 50 of about 94,759 (256)

Small Non-Coding RNAome of Ageing Chondrocytes

bioRxiv, 2020
Background Ageing is one of the leading risk factors predisposing cartilage to musculoskeletal diseases, including osteoarthritis. Cumulative evidence suggests that small non-coding RNAs play a role in cartilage-related pathological changes.
P. Balaskas, J. Green, T. Haqqi, P. Dyer, Y. A. Kharaz, Yongxiang Fang, Xuan Liu, T. Welting, M. Peffers   +8 more
semanticscholar   +1 more source

Comparison of SARS-CoV-2 sequencing using the ONT GridION and the Illumina MiSeq

BMC Genomics, 2022
Over 4 million SARS-CoV-2 genomes have been sequenced globally in the past 2 years. This has been crucial in elucidating transmission chains within communities, the development of new diagnostic methods, vaccines, and antivirals.
D. Tshiabuila, J. Giandhari, S. Pillay, U. Ramphal, Yajna Ramphal, Arisha Maharaj, U. J. Anyaneji, Y. Naidoo, H. Tegally, E. J. San, E. Wilkinson, R. Lessells, Tulio de Oliveira   +12 more
semanticscholar   +1 more source

Sequencing error profiles of Illumina sequencing instruments

NAR Genomics and Bioinformatics, 2021
Sequencing technology has achieved great advances in the past decade. Studies have previously shown the quality of specific instruments in controlled conditions.
Nicholas Stoler, A. Nekrutenko
semanticscholar   +1 more source

Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection [PDF]

, 2013
Streptococcus pneumoniae of serotype 3 possess a mucoid capsule and cause disease associated with high mortality rates relative to other pneumococci. Phylogenetic analysis of a complete reference genome and 81 draft sequences from clonal complex 180, the
Barquist, L, Bentley, SD, Browall, S, Croucher, NJ, Dordel, J, Feltwell, T, Fookes, MC, Gould, KA, Harris, SR, Henriques-Normark, B, Hinds, J, Inverarity, D, Mitchell, AM, Mitchell, TJ, Normark, S, Parkhill, J, Salter, SJ, Zemlickova, H   +17 more
core   +4 more sources

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Clinical value of metagenomic next-generation sequencing by Illumina and Nanopore for the detection of pathogens in bronchoalveolar lavage fluid in suspected community-acquired pneumonia patients

Frontiers in Cellular and Infection Microbiology, 2022
At present, metagenomic next-generation sequencing (mNGS) based on Illumina platform has been widely reported for pathogen detection. There are few studies on the diagnosis of major pathogens and treatment regulation using mNGS based on Illumina versus ...
Jing Zhang, Lin Gao, Chi Zhu, Jiajia Jin, Chao Song, Hang Dong, Zhenzhong Li, Zheng Wang, Yubao Chen, Zhenhua Yang, Yan Tan, Li Wang   +11 more
semanticscholar   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]

, 2017
Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S, Arron, Sarah T, Chang, David S, Gupta, Rashmi, Lai, Kevin, Lee, Kristina M, Liao, Wilson, Nititham, Joanne, Rosenblum, Michael, Taravati, Keyon   +9 more
core   +1 more source

Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease [PDF]

, 2020
Enteroaggregative E. coli (EAEC) are a major cause of diarrhoea worldwide. Due to their heterogeneity and carriage in healthy individuals, identification of diagnostic virulence markers for pathogenic strains has been difficult.
Brett, Bernard, Bundy, Leah, Chattaway, Marie A., Crossman, Lisa C., Ellis, Samuel J., Hölken, Johanna M., Kay, Gemma L., McGrath, Conor J., Schüller, Stephanie, Wain, John   +9 more
core   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source