Results 151 to 160 of about 1,919,747 (271)
Éditer les Illustrations de Gaule et Singularitez de Troye de Jean Lemaire de Belges
, 2020 Adeline Desbois‐Ientile +1 more
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Le rite français, tome V. Les grades de sagesse du rite primordial de France de l’élu secret au grand élu écossais. Voyage à travers le II e Ordre, esprit de synthèse. Hervé Vigier, Éditions Télètes, Coll. Défense et illustration de la Maçonnerie française, 2020, 108 pages, 18 € [PDF]
, 2020 Yonnel Ghernaouti
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Surgical Paradigms in Diffuse Low-grade Glioma: Insular Glioma Case Illustration [PDF]
, 2021 Nardin Samuel +3 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
History and Bibliography of Anatomic Illustration in Its Relation to Anatomic Science and the Graphic Arts. Ludwig Choulant, Mortimer Frank [PDF]
, 1921 G. S.
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