Results 41 to 50 of about 599,096 (309)

Autophagy in cancer and protein conformational disorders

open access: yesFEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

The Illustrated Fiction between 19th and 20th Century

open access: yesBetween, 2023
The issue The Illustrated Fiction between the 19th and 20th Century fits into the fields of the icono-textual and visual studies. It focuses on the publishing choices in the 19th and 20th centuries and their aesthetic implications.
Claudia Cao   +2 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

A Conspiracy with Twelve-Year-Old Jane Austen: Juliet McMaster’s Illustrations for ‘The Beautifull Cassandra’

open access: yesHumanities, 2022
This article discusses a picture book, The Beautifull [sic] Cassandra, that was published by Juvenilia Press in 2021. The text was written by Jane Austen, most probably in 1788, and was edited and illustrated by Juliet McMaster some 200 years later.
Kazuko Hisamori
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

A Look at Matisse Methods in Poetry Illustration [PDF]

open access: yesپیکره, 2012
This article introduces and studies a different aspect of the works of a twen-tieth century artist called Henry Matisse. In addition to the special status of Matisse in twentieth century  paintings, he had accepted many book illustra-tions which were ...
Hojatallah Saadatfar
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

A Study of Implementation Methods in Title Sequence and the Ways it Relates to its Respective Movie [PDF]

open access: yesپیکره, 2013
As important as it may seem’ categorizing title sequences based on their technique and relation to their respective movies is not paid enough attention yet.
Kian Ashrafi
doaj   +1 more source

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