Results 221 to 230 of about 1,005,742 (306)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality. [PDF]

PLoS Biol
Bergmann C, Häsler LM, Lambert M, Kaeser SA, Schultz SA, Riond B, Weiss M, Balz M, Knauf-Witzens T, Jucker M.   +9 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A qualitative review of Fitzpatrick skin types featured on the front covers of the British Association of Dermatologists journals. [PDF]

Skin Health Dis
Nolan B.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Integrating the behavior change wheel and co-design approach in selecting strategies for improving cervical cancer screening literacy among rural women living with HIV in Eastern Uganda. [PDF]

BMC Health Serv Res
Namutundu J, Nakalembe M, Nakku-Joloba E, Kiguli J, Nangendo J, Laker-Oketta M, Semeere A, Wanyenze RK, Semitala FC.   +8 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Indigenous Peoples and local communities as agents of transformative change for sustainability. [PDF]

Commun Earth Environ
Reyes-García V, Nelson V, Bonilla-Moheno M, Hausner VH, Leventon J, Wheeler HC, Aksoy Z, Bates P, Carino J, Dabezies JM, Frantzeskaki N, Gordon E, Gosnell H, Guibal C, Gurung J, Heatta MJ, Hernandez Y, Huambachano M, Ifejika Speranza C, A Magris R, Mannetti L, Mansur AV, Nishi M, O'Brien K, Pictou S, Raab K, Roskruge N, Sulyandziga R, Villasante S.   +28 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source