Results 91 to 100 of about 2,142,655 (322)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Internal thread defect detection system based on multi-vision.

PLoS ONE
In the realm of industrial inspection, the precise assessment of internal thread quality is crucial for ensuring mechanical integrity and safety. However, challenges such as limited internal space, inadequate lighting, and complex geometry significantly ...
Xiaohan Dou, Chengqi Xue, Gengpei Zhang, Zhihao Jiang   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Lighting System Control for Cataract Maturity Imaging Device

Journal of Electrical Engineering and Computer
As technology advances, various innovations have been made to assist in diagnosing and treating cataracts. In cataract detection, artificial intelligence-based methods such as Convolutional Neural Networks (CNN) have proven very effective in detecting ...
Katon Bagus Setiawan, I Komang Somawirata, Irmalia Suryani Faradisa   +2 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A Joint Suppression Method of Scalloping and Inter-Scan Banding for SAR Images

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Due to a wide swath at the order of hundreds of kilometres, interscan banding (ISB) may occur in both ScanSAR and TOPS modes of a synthetic aperture radar (SAR), leading to degraded image quality. In this aticle, the causes of ISB are analyzed and an ISB
Xinwei An, Wei Yang, Haijun Shen, Hongcheng Zeng, Fei Zou, Jiadong Deng, Can Su, Wei Liu   +7 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Image Based Lighting using HDR-video

, 2013
It has been widely recognized that lighting plays a key role in the realism and visual interest of computer graphics renderings. This hasled to research and development of image based lighting (IBL) techniques where the illumination conditions in real world scenes are captured as high dynamic range (HDR) image panoramas and used as lighting information
Unger, Jonas, Kronander, Joel, Larsson, Per, Gustavson, Stefan, Ynnerman, Anders   +4 more
openaire   +1 more source

Vehicle detection framework for challenging lighting driving environment based on feature fusion method using adaptive neuro-fuzzy inference system

International Journal of Advanced Robotic Systems, 2018
This article proposes a new preceding vehicle detection framework for challenging lighting environments using a novel feature fusion technique based on an adaptive neuro-fuzzy inference system.
Dong Sung Pae, In Hwan Choi, Tae Koo Kang, Myo Taeg Lim   +3 more
doaj   +1 more source