The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
Benchmarking Accelerometer and CNN-Based Vision Systems for Sleep Posture Classification in Healthcare Applications. [PDF]
Hoang ML+4 more
europepmc +1 more source
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu+12 more
wiley +1 more source
Zero-shot instance segmentation for plant phenotyping in vertical farming with foundation models and VC-NMS. [PDF]
Bao QZ, Yang YX, Li Q, Yang HC.
europepmc +1 more source
Image Segmentation for Uneven Lighting Images based on Initial Window Size Selection
Rashmi Saini
openalex +1 more source
The Regulation of Trace Metal Elements in Cancer Ferroptosis
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang+5 more
wiley +1 more source
Nighttime light intensity and brightness suitability in urban functional zones. [PDF]
Liu M+5 more
europepmc +1 more source
Characterization of a quasi-real-time lighting computing system based on HDR imaging
Yujie Wu+2 more
openalex +1 more source
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang+8 more
wiley +1 more source
The Initial Attitude Estimation of an Electromagnetic Projectile in the High-Temperature Flow Field Based on Mask R-CNN and the Multi-Constraints Genetic Algorithm. [PDF]
Chen J, Yu M, Guo Y, Gao C.
europepmc +1 more source