Results 101 to 110 of about 13,444,099 (340)

Causal discovery reveals complex patterns of drought-induced displacement

iScience
Summary: The increasing frequency and severity of droughts present a significant risk to vulnerable regions of the globe, potentially leading to substantial human displacement in extreme situations.
Jose María Tárraga, Eva Sevillano-Marco, Jordi Muñoz-Marí, María Piles, Vasileios Sitokonstantinou, Michele Ronco, María Teresa Miranda, Jordi Cerdà, Gustau Camps-Valls   +8 more
doaj   +1 more source

Quantitative mapping and minimization of super-resolution optical imaging artifacts [PDF]

, 2018
S J Culley, David Albrecht, Caron Jacobs, Pedro M. Pereira, Christophe Leterrier, Jason Mercer, Ricardo Henriques   +6 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems [PDF]

, 2019
Liang-Zhong Yang, Yang Wang, Siqi Li, Run-Wen Yao, Peng-Fei Luan, Huang Wu, Gordon Carmichael, Ling‐Ling Chen   +7 more
openalex   +1 more source

Deep learning for biomedical photoacoustic imaging: A review

, 2021
Janek Gröhl, Melanie Schellenberg, Kris Dreher, Lena Maier-Hein, Janek Gröhl, Melanie Schellenberg, Kris Dreher, Lena Maier-Hein   +7 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Deep learning methods for noisy sperm image classification from convolutional neural network to visual transformer: a comprehensive comparative study

Intelligent Medicine
Background With the gradual increase of infertility in the world, among which male sperm problems are the main factor for infertility, more and more couples are using computer-assisted sperm analysis (CASA) to assist in the analysis and treatment of ...
Ao Chen, Chen Li, Md Mamunur Rahaman, Yudong Yao, Haoyuan Chen, Hechen Yang, Peng Zhao, Weiming Hu, Wanli Liu, Shuojia Zou, Ning Xu, Marcin Grzegorzek   +11 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source