Results 181 to 190 of about 13,444,099 (340)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Introducing an efficient method for feature extraction in image retrieval systems. [PDF]

Sci Rep
Zhao X, He F, Li K.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Image adaptive encryption using EfficientNet B3 feature guided multi scroll chaotic map with modulo controlled pseudo parallel processing. [PDF]

Sci Rep
Subathra S, Thanikaiselvan V.
europepmc   +1 more source

A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues

, 2016
Peng Tao, Xingmiao Chen, Lei Gao, Ting Zhang, Wei Wang, Jiangang Shen, Dan Yang   +6 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

UIGen: a hybrid framework for underwater image encryption based on evolutionary chaotic system and multi-domain transformation. [PDF]

Sci Rep
Khokhar P, Bedi J, Batra S.
europepmc   +1 more source

High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation

, 2014
David Staudt, Jiandong Liu, Kurt S. Thorn, Nico Stuurman, Michael Liebling, Didier Y. R. Stainier   +5 more
openalex   +1 more source

New Brodatz-Based Image Databases for Grayscale Color and Multiband Texture Analysis [PDF]

, 2013
Abdelmounaime Safia, Dong-Chen He
openalex   +1 more source

Images

Perception, 1993
openaire   +2 more sources