Results 51 to 60 of about 13,444,099 (340)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

open access: yesFEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz   +5 more
wiley   +1 more source

Image Sensor [PDF]

open access: yes, 2017
A CCD image sensor of the type for providing charge multiplication by impact ionisation has an image area and a plurality of pixels. A separate multiplication register has a plurality of multiplication elements arranged to receive charge from the pixels ...
Jerram, Paul, Stefanov, Konstantin
core  

Hierarchy-based Image Embeddings for Semantic Image Retrieval

open access: yes, 2019
Deep neural networks trained for classification have been found to learn powerful image representations, which are also often used for other tasks such as comparing images w.r.t. their visual similarity. However, visual similarity does not imply semantic
Barz, Björn, Denzler, Joachim
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Actively pulse shaped linearly polarized nanosecond hybrid Ho3+ and Tm3+-doped silica fiber & Ho3+:YAG MOPA at 2048 nm [PDF]

open access: yesEPJ Web of Conferences
Ho3+:YAG amplifiers are able to efficiently scale pulse energy at wavelengths far shorter than the main emission peak. For 24 W input power at 2048 nm a signal output power of 81.6 W is reached, resulting in 5.3 dB gain.
Lorenz Dominik   +8 more
doaj   +1 more source

An unambiguous cloudiness index for nonwovens

open access: yesJournal of Mathematics in Industry, 2022
Cloudiness or formation is a concept routinely used in industry to address deviations from homogeneity in nonwovens and papers. Measuring a cloudiness index based on image data is a common task in industrial quality assurance.
Michael Godehardt   +4 more
doaj   +1 more source

Tractography-based navigated TMS language mapping protocol

open access: yesFrontiers in Oncology, 2022
IntroductionThis study explores the feasibility of implementing a tractography-based navigated transcranial magnetic stimulation (nTMS) language mapping protocol targeting cortical terminations of the arcuate fasciculus (AF).
Klara Reisch   +8 more
doaj   +1 more source

Hiding Images within Images [PDF]

open access: yesIEEE Transactions on Pattern Analysis and Machine Intelligence, 2020
We present a system to hide a full color image inside another of the same size with minimal quality loss to either image. Deep neural networks are simultaneously trained to create the hiding and revealing processes and are designed to specifically work as a pair.
openaire   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

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