Results 111 to 120 of about 11,867,254 (282)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

An Image Annotation Method Based on CM Similarity Measure and Hybrid Relevance Feedback

open access: yesInternational Journal of Information and Communication Technology Research, 2011
Today, with the advent of digital imagery, the volume of digital images has been growing rapidly in different fields. So, there is an increasing need for providing an effective image retrieval system.
Mehran Javani   +1 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Visual big data mining: toward next-generation multi-label image annotation and retrieval using Quantum Firefly optimization

open access: yesJournal of Big Data
This study presents a Quantum-Enhanced Firefly Algorithm (QFA)-based multi-level image annotation framework that integrates advanced Otsu thresholding, region-based feature extraction, and Bayesian multi-label classification.
Lina J. Abu Shaheen   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

RapidX annotator: A specialized software tool for industrial radiographic image annotation and enhancement

open access: yesSoftwareX
Radiographic testing (RT) plays a vital role in non-destructive evaluation (NDT), yet the interpretation and annotation of radiographic images remain time-consuming and error-prone.
Yan Li   +4 more
doaj   +1 more source

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