Results 41 to 50 of about 129,731 (262)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Journal of Pathology Informatics, 2011 Histopathological images are an important resource for clinical diagnosis and biomedical research. From an image understanding point of view, the automatic annotation of these images is a challenging problem.
Angel Cruz-Roa +3 more
doaj +1 more source
Annotation of enhanced radiographs for medical image retrieval with deep convolutional neural networks. [PDF]
PLoS ONE, 2018 The number of images taken per patient scan has rapidly increased due to advances in software, hardware and digital imaging in the medical domain.
Obioma Pelka +2 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Automated Annotator Variability Inspection for Biomedical Image Segmentation
IEEE Access, 2022 Supervised deep learning approaches for automated diagnosis support require datasets annotated by experts. Intra-annotator variability of a single annotator and inter-annotator variability between annotators can affect the quality of the diagnosis ...
Marcel P. Schilling +6 more
doaj +1 more source
Hierarchical annotation of medical images [PDF]
Pattern Recognition, 2011 We present a hierarchical multi-label classification (HMC) system for medical image annotation. HMC is a variant of classification where an instance may belong to multiple classes at the same time and these classes/labels are organized in a hierarchy. Our approach to HMC exploits the annotation hierarchy by building a single predictive clustering tree (
Ivica Dimitrovski +3 more
openaire +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Web-Scale Image Annotation [PDF]
, 2008 In this paper, we describe our experiments using Latent Dirichlet Allocation (LDA) to model images containing both perceptual features and words. To build a large-scale image tagging system, we distribute the computation of LDA parameters using MapReduce.
Jiakai Liu +4 more
openaire +1 more source