Results 71 to 80 of about 496,156 (331)

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Synthesizing brain tumor images and annotations by combining progressive growing GAN and SPADE [PDF]

open access: yesarXiv, 2020
Training segmentation networks requires large annotated datasets, but manual annotation is time consuming and costly. We here investigate if the combination of a noise-to-image GAN and an image-to-image GAN can be used to synthesize realistic brain tumor images as well as the corresponding tumor annotations (labels), to substantially increase the ...
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Automatic annotation of histopathological images using a latent topic model based on non-negative matrix factorization

open access: yesJournal of Pathology Informatics, 2011
Histopathological images are an important resource for clinical diagnosis and biomedical research. From an image understanding point of view, the automatic annotation of these images is a challenging problem.
Angel Cruz-Roa   +3 more
doaj   +1 more source

Trapalyzer: a computer program for quantitative analyses in fluorescent live-imaging studies of neutrophil extracellular trap formation

open access: yesFrontiers in Immunology, 2023
Neutrophil extracellular traps (NETs), pathogen-ensnaring structures formed by neutrophils by expelling their DNA into the environment, are believed to play an important role in immunity and autoimmune diseases.
Michał Aleksander Ciach   +6 more
doaj   +1 more source

Linking Text and Image with SVG [PDF]

open access: yes, 2009
Annotation and linking (or referring) have been described as "scholarly primitives", basic methods used in scholarly research and publication of all kinds.
Cayless, Hugh A.
core  

Multi-Modal Multi-Scale Deep Learning for Large-Scale Image Annotation

open access: yes, 2018
Image annotation aims to annotate a given image with a variable number of class labels corresponding to diverse visual concepts. In this paper, we address two main issues in large-scale image annotation: 1) how to learn a rich feature representation ...
Chang, Shih-Fu   +4 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Multi‐domain autonomous driving dataset: Towards enhancing the generalization of the convolutional neural networks in new environments

open access: yesIET Image Processing, 2023
In this paper, a large‐scale dataset called the Iran Autonomous Driving Dataset (IADD) is presented, aiming to improve the generalization capability of the deep networks outside of their training domains.
Amir Khosravian   +3 more
doaj   +1 more source

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