Results 71 to 80 of about 7,122,625 (292)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improvement of Gastroscopy Classification Performance Through Image Augmentation Using a Gradient-Weighted Class Activation Map

IEEE Access, 2022
Endoscopic specialists performing gastroscopy, which relies on the naked eye, may benefit from a computer-aided diagnosis (CADx) system that employs deep learning.
Hyun-Sik Ham, Han-sung Lee, Jung-Woo Chae, H. Cho, Hyun-chong Cho   +4 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Deep Learning Image Augmentation Method for Field Agriculture

IEEE Access
Vision-based smart agriculture is an important way to improve the efficiency of agricultural production. Labeling images for deep learning in complex field photos is a difficult task.
Kunlin Zou, Yi Shan, Xun Zhao, D. Ran, Xiaoxi Che   +4 more
semanticscholar   +1 more source

Data acquisition system for OLED defect detection and augmentation of system data through diffusion model

Journal of Information Display
This paper presents a system and model for data acquisition and augmentation in OLED panel defect detection to improve detection efficiency. It addresses the challenges of data scarcity, data acquisition difficulties, and classification of different ...
Byungjoon Kim, Yongduek Seo
doaj   +1 more source

Ensemble Deep Learning for the Detection of COVID-19 in Unbalanced Chest X-ray Dataset

Applied Sciences, 2021
The ongoing COVID-19 pandemic has caused devastating effects on humanity worldwide. With practical advantages and wide accessibility, chest X-rays (CXRs) play vital roles in the diagnosis of COVID-19 and the evaluation of the extent of lung damages ...
Khin Yadanar Win, Noppadol Maneerat, Syna Sreng, Kazuhiko Hamamoto   +3 more
doaj   +1 more source

Data augmentation and image understanding

CoRR, 2020
Interdisciplinary research is often at the core of scientific progress. This dissertation explores some advantageous synergies between machine learning, cognitive science and neuroscience. In particular, this thesis focuses on vision and images. The human visual system has been widely studied from both behavioural and neuroscientific points of view, as
openaire   +3 more sources

Deep Image Harmonization with Learnable Augmentation

2023 IEEE/CVF International Conference on Computer Vision (ICCV), 2023
Accepted by ICCV ...
Li Niu 0002, Junyan Cao, Wenyan Cong, Liqing Zhang 0001   +3 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source