Results 111 to 120 of about 12,352,701 (307)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A Variational Model for Sea Image Enhancement
, 2018 The purpose of sea image enhancement is to enhance the information of the waves, whose contrast is generally weak. Enhancement effect is often affected by impulse-type noise and non-uniform illumination.
Hongsong Qu +4 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Speckle Reduction with Attenuation Compensation for Skin OCT Images Enhancement [PDF]
The enhancement of skin image in optical coherence tomography (OCT) imaging can help dermatologists to investigate tissue layers more accurately, hence the more efficient diagnosis.
Hojjatoleslami, Ali +1 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Locally-equalized image contrast enhancement using PSO-tuned sectorized equalization
, 2012 © 2013 Springer-Verlag Berlin Heidelberg. All rights are reserved. Contrast enhancement is a fundamental procedure in applications requiring image processing.
Kwok, NM +14 more
core +1 more source
DEDU: Dual-Enhancing Dense-UNet for Lowlight Image Enhancement and Denoise
IEEE AccessIn this paper, we propose an innovative image enhancement algorithm called “Dual-Enhancing-Dense-UNet (DEDUNet)” that simultaneously performs image brightness enhancement and reduces noise.
Hyungjoo Park +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source