Results 41 to 50 of about 277,259 (259)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Near-Infrared Fluorescent Digital Pathology for the Automation of Disease Diagnosis and Biomarker Assessment

Molecular Imaging, 2015
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high.
Summer L. Gibbs, Elizabeth Genega, Jeffery Salemi, Vida Kianzad, Haley L. Goodwill, Yang Xie, Rafiou Oketokoun, Parmeshwar Khurd, Ali Kamen, John V. Frangioni   +9 more
doaj   +1 more source

The pragmatic proof: hypermedia API composition and execution [PDF]

, 2016
Machine clients are increasingly making use of the Web to perform tasks. While Web services traditionally mimic remote procedure calling interfaces, a new generation of so-called hypermedia APIs works through hyperlinks and forms, in a way similar to how
Arndt, Dorthe, De Roo, Jos, Gabarró Vallès, Joaquim, Mels, Giovanni, Steiner, Thomas, Van Hoecke, Sofie, Verborgh, Ruben   +6 more
core   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

AI-based CT assessment of 3117 vertebrae reveals significant sex-specific vertebral height differences

Scientific Reports
Predicting vertebral height is complex due to individual factors. AI-based medical imaging analysis offers new opportunities for vertebral assessment. Thereby, these novel methods may contribute to sex-adapted nomograms and vertebral height prediction ...
Viktoria Palm, Subasini Thangamani, Bettina Katalin Budai, Stephan Skornitzke, Kira Eckl, Elizabeth Tong, Sam Sedaghat, Claus Peter Heußel, Oyunbileg von Stackelberg, Sandy Engelhardt, Taisiya Kopytova, Tobias Norajitra, Klaus H. Maier-Hein, Hans-Ulrich Kauczor, Mark Oliver Wielpütz   +14 more
doaj   +1 more source

Mobile learning: benefits of augmented reality in geometry teaching [PDF]

, 2018
As a consequence of the technological advances and the widespread use of mobile devices to access information and communication in the last decades, mobile learning has become a spontaneous learning model, providing a more flexible and collaborative ...
Leitão, Rui, Marcos, Adérito, Rodrigues, Joao M. F.   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Enhancing deep learning methods for brain metastasis detection through cross-technique annotations on SPACE MRI

European Radiology Experimental
Background Gadolinium-enhanced “sampling perfection with application-optimized contrasts using different flip angle evolution” (SPACE) sequence allows better visualization of brain metastases (BMs) compared to “magnetization-prepared rapid acquisition ...
Tassilo Wald, Benjamin Hamm, Julius C. Holzschuh, Rami El Shafie, Andreas Kudak, Balint Kovacs, Irada Pflüger, Bastian von Nettelbladt, Constantin Ulrich, Michael Anton Baumgartner, Philipp Vollmuth, Jürgen Debus, Klaus H. Maier-Hein, Thomas Welzel   +13 more
doaj   +1 more source

The Bionic Radiologist: avoiding blurry pictures and providing greater insights [PDF]

, 2019
Radiology images and reports have long been digitalized. However, the potential of the more than 3.6 billion radiology examinations performed annually worldwide has largely gone unused in the effort to digitally transform health care.
Dewey, Marc, Wilkens, Uta
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source