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Department of Applied Mathematics and Statistics newsletter, September 11, 2023

open access: yes, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Pixel programming aspects of digital image

open access: yesLietuvos Matematikos Rinkinys, 2012
This article describes a realization of the mathematics and informatics subjects by using visual objective programming facilities. For solving advanced computer graphics tasks, seems comfortable to use new estimated mathematics programs and packages ...
Rima Birškytė
doaj   +1 more source

The Promise of Qualitative Metasynthesis: Mathematics Experiences of Black Learners

open access: yesJournal of Mathematics Education at Teachers College, 2013
The purpose of this article is to present the findings of a qualitative metasynthesis focused on Black learners negotiating their mathematics experiences in multiple settings (in school and out-of-school) and reflecting on experiences that contributed ...
Robert Berry, Kateri Thunder
doaj   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Cloud Detection Challenge-Methods and Results

open access: yesIEEE Access
Accurate cloud detection is critical for advancing atmospheric monitoring and meteorological forecasting. This paper presents the Cloud Detection Challenge, an initiative aimed at enhancing cloud detection through innovative solutions using lidar-based ...
Alessio Barbaro Chisari   +9 more
doaj   +1 more source

Effect of Hyperspectral Data Compression on Data Pre-processing: Analysis of Reconstruction Error Propagation [PDF]

open access: yesISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Hyperspectral imaging platforms such as UAVs and small satellites face strict constraints in data transmission and onboard storage. Lossy compression applied directly to raw sensor measurements offers substantial benefits for bandwidth efficiency ...
J. Kuester   +7 more
doaj   +1 more source

Department of Applied Mathematics and Statistics newsletter, October 30, 2023 [PDF]

open access: yes, 2023
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...

core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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