Results 141 to 150 of about 263,197 (303)

Complex Genetic Architecture in RASopathies: Constitutional PTPN11 and Mosaic RIT1 Pathogenic Variants Underlying Severe Noonan Syndrome With Adult‐Onset Acute Myeloid Leukemia

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) is a genetically heterogeneous disorder characterized by a broad spectrum of clinical features resulting from dysregulation of the RAS/MAPK pathway. Although complex genotypes are increasingly recognized in NS, cases harboring two distinct pathogenic variants in different NS genes remain extremely rare.
Francesco Prevedello   +10 more
wiley   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam   +4 more
wiley   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang   +14 more
wiley   +1 more source

Image mosaicing

open access: yes, 2001
In this thesis, our focus is on feature-based 2D image mosaicing. A novel image representation scheme, which organizes a hierarchical set of features as morphological regions, edge contours and corners, is proposed for composing the feature set.
openaire   +1 more source

Magnetron Sputtering Synthesis of La‐Doped BiFeO3 Thin Films and Enhanced Exchange Bias in CoFeB/Bi1‐xLaxFeO3 Heterostructures

open access: yesAdvanced Physics Research, EarlyView.
This study explores the epitaxial growth of high‐quality La‐doped BiFeO3 (BLFO) thin films at 550 °C using magnetron sputtering. The films exhibit good ferroelectric properties and low leakage current. A BLFO/CoFeB heterostructure is constructed, achieving an exchange bias field exceeding the coercive field at room temperature.
Zhiqin Zhou   +10 more
wiley   +1 more source

Seamline Optimization Based on Triangulated Irregular Network of Tiepoints for Fast UAV Image Mosaicking

open access: yesRemote Sensing
UAV remote sensing is suitable for urgent image monitoring and periodic observation of an area of interest. To observe a target area using UAVs, many images must be acquired because of the narrow image coverage of UAVs.
Sung-Joo Yoon, Taejung Kim
doaj   +1 more source

Functional models from limited data: A parametric and multimodal approach to anatomy and 3D kinematics of feeding in basking sharks (Cetorhinus maximus)

open access: yesThe Anatomical Record, EarlyView.
Abstract Basking sharks, Cetorhinus maximus (Gunnerus, Brugden [Squalus maximus], Det Kongelige Norske Videnskabers Selskabs Skrifter, 1765, vol. 3, pp. 33–49), feed by gaping their mouths and gill slits, greatly reorienting their cranial skeletons to filter food from water.
Tairan Li   +12 more
wiley   +1 more source

Description of the skull, braincase, and dentition of Moschognathus whaitsi (Dinocephalia, Tapinocephalia), and its palaeobiological and behavioral implications

open access: yesThe Anatomical Record, EarlyView.
Abstract A subadult Moschognathus whaitsi from the Eastern Cape Province, South Africa, was scanned using synchrotron radiation X‐ray computed tomography (SRXCT). Its subadult state allowed the cranial bones and teeth to be identified and individually reconstructed in 3D.
Tristen Lafferty   +3 more
wiley   +1 more source

The revision of baphetids from the Middle Pennsylvanian of the Czech Republic: Morphology, ontogeny, palaeoecology, and the reassessment of the phylogeny of Baphetoidea

open access: yesThe Anatomical Record, EarlyView.
Abstract The baphetoids represent a clade of the Carboniferous stem‐tetrapods (Middle Mississippian—Middle Pennsylvanian) with a characteristic extension of the orbits into antorbital vacuities, which formed keyhole‐shaped openings on the skull. The more derived baphetids were crocodile‐like piscivores frequently occurring in coal‐bearing lacustrine ...
Pavel Barták, Martin Ivanov, Boris Ekrt
wiley   +1 more source

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