Results 131 to 140 of about 376,443 (285)

Imagery-37: a virtual lab for computer assisted education on digital image processing

Industrial Data, 2008
Imagery is a Virtual Lab for computer-assisted traning on Digital Image Processing(DIP), currently including 37 modules. Thhis software allows the user in the effects on real images; it may be used in the classroom, in the laboratory or at home. Imagery not only operates on images included by its creator(the author of this report), but also on those ...
openaire   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Radiomics workflow definition & challenges - German priority program 2177 consensus statement on clinically applied radiomics

Insights into Imaging
Objectives Achieving a consensus on a definition for different aspects of radiomics workflows to support their translation into clinical usage. Furthermore, to assess the perspective of experts on important challenges for a successful clinical workflow ...
Ralf Floca, Jonas Bohn, Christian Haux, Benedikt Wiestler, Frank G. Zöllner, Annika Reinke, Jakob Weiß, Marco Nolden, Steffen Albert, Thorsten Persigehl, Tobias Norajitra, Bettina Baeßler, Marc Dewey, Rickmer Braren, Martin Büchert, Eva Maria Fallenberg, Norbert Galldiks, Annika Gerken, Michael Götz, Horst K. Hahn, Johannes Haubold, Tobias Haueise, Nils Große Hokamp, Michael Ingrisch, Andra-Iza Iuga, Marco Janoschke, Matthias Jung, Lena Sophie Kiefer, Philipp Lohmann, Jürgen Machann, Jan Hendrik Moltz, Johanna Nattenmüller, Tobias Nonnenmacher, Benedict Oerther, Ahmed E. Othman, Felix Peisen, Fritz Schick, Lale Umutlu, Barbara D. Wichtmann, Wenzhao Zhao, Svenja Caspers, Heinz-Peter Schlemmer, Christopher L. Schlett, Klaus Maier-Hein, Fabian Bamberg   +44 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Introduction to the special section on computer vision for intravascular and intracardiac imaging [PDF]

, 2008
Kakadiaris, Ioannai, Slabaugh, Greg, Tannenbaum, Allen, Unal, Gozde, Ünal, Gözde   +4 more
core   +2 more sources

[Computer-assisted image processing for quantifying histopathologic variables in the healing of colonic anastomosis in dogs].

Revista da Associacao Medica Brasileira (1992), 1998
The authors present the experimental results of the computerized quantifying of tissular structures involved in the reparative process of colonic anastomosis performed by manual suture and biofragmentable ring. The quantified variables in this study were: oedema fluid, myofiber tissue, blood vessel and cellular nuclei.An image processing software ...
M D, Novelli, E, Barreto, D, Matos, S S, Saad, R C, Borra   +4 more
openaire   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source