A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Artificial Intelligence Meets Nail Diagnostics: Emerging Image-Based Sensing Platforms for Non-Invasive Disease Detection. [PDF]
Marode TP +9 more
europepmc +1 more source
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla +13 more
wiley +1 more source
Automated Implant Placement Pathway from Dental Panoramic Radiographs Using Deep Learning for Preliminary Clinical Assistance. [PDF]
Wu PY +9 more
europepmc +1 more source
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma +7 more
wiley +1 more source
AI applications in lumbar and lumbosacral pedicle screw placement: a systematic review of limited evidence and future directions. [PDF]
Thintharua P +4 more
europepmc +1 more source
Guidelines for the adoption of digital pathology in clinical pathology units recommended by the polish society of pathologists. [PDF]
Szylberg Ł +5 more
europepmc +1 more source
SDXL model-based optimization for interior design: Data-driven and deep learning methods. [PDF]
Zhou X, Kim S, Chen Y.
europepmc +1 more source
A hybrid approach for accurate skin lesion segmentation using LEDNet and Swin-UMamba. [PDF]
Naeem MA +4 more
europepmc +1 more source
Evaluating deep learning models for pancreatic cancer diagnosis. [PDF]
Li D, He H, Hu J, Ding Y, Kong L, Hu A.
europepmc +1 more source

