Results 251 to 260 of about 473,139 (306)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Deep Convolutional Backbone Comparison for Automated PET Image Quality Assessment. [PDF]

open access: yesIEEE Trans Radiat Plasma Med Sci
Hopson JB   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A fully automated, expert-perceptive image quality assessment system for whole-body [18F]FDG PET/CT. [PDF]

open access: yesEJNMMI Res
Zhang C   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Image quality assessment and automation in late gadolinium-enhanced MRI of the left atrium in atrial fibrillation patients. [PDF]

open access: yesJ Interv Card Electrophysiol
Orkild B   +10 more
europepmc   +1 more source

Open ultrawidefield fundus image dataset with disease diagnosis and clinical image quality assessment. [PDF]

open access: yesSci Data
He S   +9 more
europepmc   +1 more source

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