Results 81 to 90 of about 6,693,779 (355)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ROCA: Robust CAD Model Retrieval and Alignment from a Single Image [PDF]
, 2021 Can Gümeli +2 more
openalex +1 more source
Content-Based Image Retrieval and Feature Extraction: A Comprehensive Review
Mathematical Problems in Engineering, 2019 Multimedia content analysis is applied in different real-world computer vision applications, and digital images constitute a major part of multimedia data.
Afshan Latif +9 more
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Image-Text Retrieval Backdoor Attack with Diffusion-Based Image-Editing [PDF]
Jisuanji kexue yu tansuoDeep neural networks are susceptible to backdoor attacks during the training stage. When training an image-text retrieval model, if an attacker maliciously injects image-text pairs with a backdoor trigger into the training dataset, the backdoor will be ...
YANG Shun, LU Hengyang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
THE IMAGE RETRIEVAL OBJECT GANESHA IMAGE USING INVARIANT MOMENT METHOD
Jurnal Ilmiah Kursor: Menuju Solusi Teknologi Informasi, 2017 In the findings of the statue of Ganesha in Trowulan Mojokerto area is no longer intact, because the statue of Ganesha is found to have been on the surface of soil or underground, so the archaeologist is very difficult to categorize the findings.
Hendro Nugroho, Eka Prakarsa Mandyartha
doaj +1 more source