Results 221 to 230 of about 6,300,985 (321)

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo   +15 more
wiley   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

open access: yesAdvanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen   +9 more
wiley   +1 more source

Saliency Deep Embedding for Aurora Image Search [PDF]

open access: green, 2018
Xi Yang   +4 more
openalex   +1 more source

Preparation and Insight of [010]‐Orientated BiVO4 Planar Photoanode via One‐Step Pyrolysis for Significantly Promoted Charge Separation and Water Oxidation

open access: yesAdvanced Science, EarlyView.
The BiVO4 photoanode with [010]‐orientated growth is first prepared by simple metal–organic decomposition, which strikingly exhibits by far superior bulk charge separation as well as water oxidation with respect to the randomly BiVO4, showing benchmarking photocurrent density and charge separation efficiency of 97.5% at 1.23 V versus.RHE.
Sainan Zhang   +8 more
wiley   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

open access: yesAdvanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong   +15 more
wiley   +1 more source

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