Results 61 to 70 of about 11,514,111 (239)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Progressive Hybrid Automatic Switching Visual Servoing Method for Apple-Picking Robots
AgriculturePosition-Based Visual Servoing (PBVS) and Image-Based Visual Servoing (IBVS) struggle to balance end effector pose accuracy and robustness in apple picking. They are also prone to target loss and control singularities.
Jiangming Kan +7 more
doaj +1 more source
EPJ Web of Conferences, 2010 Composite materials are today used for various industrial applications. However, delamination on free edges, where stress gradients are strong, still remain a problem. In the aim of a better understanding of such phenomenons, Digital Image Correlation
Brieu M., Paluch B., Lecomte P.
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Screw dislocation in a Bi-medium within strain gradient elasticity revisited
Journal of the Mechanical Behavior of Materials, 2019 In this paper, we consider a straight screw dis-location near a flat interface between two elastic media in the framework of strain gradient elasticity (as studied by Gutkin et. al. [1]) by now taking care of some incomplete calculations).
Davoudi Kamyar M., Aifantis Elias C.
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Magnification Cross Sections for the Elliptic Umbilic Caustic Surface
Universe, 2019 In gravitational lensing, magnification cross sections characterize the probability that a light source will have magnification greater than some fixed value, which is useful in a variety of applications. The (area) cross section is known to scale as
Amir B. Aazami +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source