Results 91 to 100 of about 1,135,244 (321)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Super-resolution imaging with nanopipettes

npj Imaging
Abstract Uncovering structural information of biological systems at the nanoscale is vital for understanding their dynamics and function. Nanoscale imaging techniques that obtain structural information down to the single-molecule level under physiologically relevant conditions and without affecting the fragile structure of biomaterials are ...
Sønderskov, Steffan Møller, Klausen, Lasse Hyldgaard; id_orcid 0000-0003-3004-5958, Skaanvik, Sebastian Amland, Han, Xiaojun, Dong, Mingdong; id_orcid 0000-0002-2025-2171   +4 more
openaire   +4 more sources

A Low- and High-Resolution Terahertz Image Pair Construction Method With Gradient Fusion for Learning-Based Super-Resolution

IEEE Access, 2022
Quality and feature quantity of low- and high-resolution image pairs for training are directly related to performance of learning-based super-resolution methods.
Fei Yuan, Songbin Zhou, Taobo Cheng, Yisen Liu   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Super-Resolution Imaging [PDF]

, 2019
This chapter examines multiframe image super-resolution in a probabilistic framework. Many multiframe super-resolution algorithms begin by a point estimate of the unknown latent parameters, such as those describing the motion or the blur function. The focus of this chapter is on alternatives to this practice that can yield superior super-resolution ...
Pickup, L, Roberts, S, Zisserman, A, Capel, D   +3 more
openaire   +2 more sources

Tensor Ring Based Image Enhancement

Journal of Medical Signals and Sensors
Background: Image enhancement, including image de-noising, super-resolution, registration, reconstruction, in-painting, and so on, is an important issue in different research areas.
Farnaz Sedighin
doaj   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source