Results 81 to 90 of about 4,887 (242)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Developing Alternative Methods for Urban Imageability Research [PDF]

open access: yes, 2015
This paper discusses the devising of an alternative data collection technique for a research project that investigated the urban imageability of the World Heritage City of Kandy in Sri Lanka.
Silva, Kapila Dharmasena
core   +1 more source

Lexical-Semantic Variables Affecting Picture and Word Naming in Chinese: A Mixed Logit Model Study in Aphasia

open access: yesBehavioural Neurology, 2012
Lexical-semantic variables (such as word frequency, imageability and age of acquisition) have been studied extensively in neuropsychology to address the structure of the word production system.
Davide Crepaldi   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Word Imageability Effects on Naming: A Pilot Investigation of Beginning Readers of Turkish

open access: yes, 2000
Word imageability, a semantic variable, in naming by beginning readers of English is well documented particularly with poor readers naming high image-able words more accurately than low imageable words.
Ilhan Raman
core   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Multifunctional Hydrogel with 3D Printability, Fluorescence, Biodegradability, and Biocompatibility for Biomedical Microrobots

open access: yesMolecules
As micron-sized objects, mobile microrobots have shown significant potential for future biomedical applications, such as targeted drug delivery and minimally invasive surgery.
Gang Wang, Sisi Wang, Tao Hu, Famin Shi
doaj   +1 more source

The atmospheric “skin” of the city

open access: yesAmbiances, 2013
What is an urban atmosphere? Through an atmospherological (aesthetical-phenomenological) approach, primarily inspired by the new aesthetics (Böhme) and the new phenomenology (Schmitz), the paper investigates what creates the overall impression ...
Tonino Griffero
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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