Results 91 to 100 of about 5,822,889 (243)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
[Casernes de Qasr al-Nil (champ de Mars)], Tiré de Images, du 5 avril 1947, p. 15
, 1960 Images. [Casernes de Qasr al-Nil (champ de Mars)], Tiré de Images, du 5 avril 1947, p. 15.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 1960 Images. Tandis que l'horloge de la citadellefonctionne celle du palais "El Tahra" est arrêtée, Tiré de Images du 21 mai 1960.
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
[ancien siège des journaux al-Hilalet al-Musawwar], Tiré de Images du 14 avril 1933, p. 41
, 1960 Images. [ancien siège des journaux al-Hilalet al-Musawwar], Tiré de Images du 14 avril 1933, p. 41.
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
[Camille Saint-Saëns devant le Selamlik du Palais al-Manyal en 1909]Tiré de Images, du 16 juin 1950
, 1960 Images. [Camille Saint-Saëns devant le Selamlik du Palais al-Manyal en 1909]Tiré de Images, du 16 juin 1950.
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Statistics of gradient directions in natural images. [PDF]
, 2007 Interest in finding statistical regularities in natural images has been growing since the advent of information theory and the advancement of the efficient coding hypothesis that the human visual system is optimised to encode natural visual stimuli.
Nasrallah, A.J. +1 more
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