Results 131 to 140 of about 10,865,472 (270)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Wprowadzenie

Images
Na okładce niniejszego numeru „Images”, który oddajemy w ręce Czytelników, znajduje się kadr z reportażu autorstwa Bolesława Matuszewskiego, jednego z pionierów światowej kinematografii, teoretyka i praktyka filmowego medium.
Images Editorial Team
doaj  

Diagnostic performance of coronary calcifications on CT to rule out acute coronary syndrome in the emergency department

BMC Emergency Medicine
Background At present, the diagnosis of acute coronary syndrome (ACS) can be made by emergency physicians using the usual complementary tests, since the current troponin and electrocardiogram (ECG) protocols have been extensively tested for their safety.
Julie Paget Sentagne, Mickaël Ohana, François Severac, Pierrick Le Borgne, Erik-André Sauleau, Pascal Bilbault, Sabrina Kepka   +6 more
doaj   +1 more source

Quantitative 3D Analysis of Plant Roots Growing in Soil Using Magnetic Resonance Imaging

, 2016
Dagmar van Dusschoten, Ralf Metzner, Johannes Kochs, Johannes A. Postma, Daniel Pflugfelder, Jonas Bühler, Ulrich Schurr, Siegfried Jahnke   +7 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

[i]Legionella spp[/i]., amoebae and not-fermenting Gram negative bacteria in an Italian university hospital water system

Annals of Agricultural and Environmental Medicine, 2014
[b]Introduction. [/b]In hospital and other health care facilities, contamination of water systems by potentially infectious microorganisms, such as bacteria, viruses and protozoa, is a source of nosocomial infections, which may originate fromcolonization
Pasqualina Laganà, Gabriella Caruso, Davide Piccione, Maria Eufemia Gioffrè, Raffaella Pino, Santi Delia   +5 more
doaj  

Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by ¹⁸F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687 [PDF]

, 2015
Evan Y. Yu, Fenghai Duan, Mark Muzi, Xuan Deng, Bennett B. Chin, Joshi J. Alumkal, Mary-Ellen Taplin, Jina Taub, Ben Herman, Celestia S. Higano, Robert K. Doot, Donna Hartfeil, Philip G. Febbo, David A. Mankoff   +13 more
openalex   +1 more source

Dataset from fundus images for the study of diabetic retinopathy

, 2021
Verónica Elisa Castillo Benítez, Ingrid Castro Matto, Julio César Mello-Román, José Luis Vázquez Noguera, Miguel García-Torres, Jordan Ayala, Diego P. Pinto-Roa, Pedro E. Gardel-Sotomayor, Jacques Facon, Sebastián Alberto Grillo   +9 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Detecting Anatomical Landmarks From Limited Medical Imaging Data Using Two-Stage Task-Oriented Deep Neural Networks

, 2017
Jun Zhang, Mingxia Liu, Dinggang Shen
openalex   +2 more sources