Results 161 to 170 of about 8,550,874 (267)

Addendum to: Apport des informations audiovisuelles dans la perception et la production de la consonne /v/ par les apprenants thaïlandais du français [PDF]

SHS Web of Conferences
Tran Thi Thuy Hien, Tusnyingyong Supansa, Vilain Coriandre, Sordes Printemps, Gerber Silvain   +4 more
doaj   +1 more source

White blood cell classification using custom deep neural network and visualizing features of the images using heatmaps. [PDF]

Sci Rep
Karaddi SH, Bitra H, Bairaboina SSR, Gudibandi BR.   +3 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER. [PDF]

J Cereb Blood Flow Metab
Mehta S, Sun H, Micali N, Holden D, Fowles K, Rossano S, Zhang J, Ma C, Han P, Lee W, Duque A, Rakic P, Groman SM, Carson RE, Scheinost D, Toyonaga T.   +15 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A reference-based PET/MRI method for quantifying activation-induced changes in cerebral oxygen metabolism. [PDF]

J Cereb Blood Flow Metab
Deller G, Liu L, Hicks JW, Narciso L, Wehrli FW, Jaroszynski K, Langham MC, St Lawrence K.   +7 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A lightweight transformer-based hybrid encoder-decoder model for chest X-ray medical report generation. [PDF]

Sci Rep
Ucan M, Kaya B, Kaya M, Alhajj R.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Multimodal deep learning for inflammatory bowel disease: a new frontier in cellular and molecular biomarker discovery to clinical translation. [PDF]

J Biol Eng
Li P, Guo S, Zhang Y, Hu H, Cheng T, Xu B, Zeng K, Huang T, Dong Z, BenHuo, Lin J, Wen H, Sun B.   +12 more
europepmc   +1 more source