Results 191 to 200 of about 10,632,664 (317)

VS-FPM: Large-Format, Label-Free Virtual Histopathology Microscopy. [PDF]

open access: yesBME Front
Bendkowski C   +5 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Addendum to: Apport des informations audiovisuelles dans la perception et la production de la consonne /v/ par les apprenants thaïlandais du français [PDF]

open access: yesSHS Web of Conferences
Tran Thi Thuy Hien   +4 more
doaj   +1 more source

Generating synthetic images of human skeletal motion for pose and kinematics estimation tasks. [PDF]

open access: yesSci Data
Lavikainen J   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

Image Dataset of Microfauna in Activated Sludge. [PDF]

open access: yesSci Data
Pang Z   +7 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy