Results 61 to 70 of about 5,758,297 (346)

'Pataphysical Software: (Ridiculous) Technological Solutions for Imaginary Problems

Conference on Designing Interactive Systems, 2020
These days, whether the problem is climate change or boredom, there is an app for that. The rhetoric of problem and solution, accelerated by commercial needs and salvific tech gurus, implies that software can save the world.
M. Sicart, Irina Shklovski
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Public imagination as a modern mechanism of solidarization in the Ukrainian nation

Український соціум, 2022
The article is devoted to the pressing issue of defining modern solidarity mechanisms in the Ukrainian nation, one of which is the public imagination. The methodological basis of the presented intelligence is the scientific work of C.G. Jung, the founder
Novachenko T. V.
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Immaginari sociali e serie TV: narrazioni e visioni del sentimento nostalgico

Funes
TV series are the corollary of observation of the social world through which we encounter the various imaginaries at work in the arcana of reality.
Fabio La Rocca
doaj   +1 more source

L’empire de l’imaginaire : la fin du monde et son rapport à l’histoire dans l’œuvre de Lucian Boia

Amnis, 2022
The imaginary of the end of the world is one of the main keys to understanding the work of Lucian Boia. For this historian, the narratives of the end of the world refer, beyond their obvious differences, to the same archetypal structures, which he ...
Aurélien Portelli
doaj   +1 more source

La formación de las identidades y los imaginarios nacionales en Cuba a inicios del siglo XIX (Estudios) [PDF]

, 2011
Este trabajo analiza el proceso de nacimiento y formación de la conciencia nacional cubana desde la perspectiva del imaginario icónico, en el que tuvieron un destacado papel las imágenes que plasmaron pintores y grabadores europeos.
Andreo García, Juan
core  

Autism and the preference for imaginary worlds

Behavioral and Brain Sciences, 2022
Abstract Dubourg and Baumard mention a potential role for the human drive to systemise as a factor motivating interest in imaginary worlds. Given that hyperexpression of this trait has been linked with autism (Baron-Cohen, 2002, 2006), we think this raises interesting implications for how those on the autism spectrum may differ from the neurotypical
Heather Browning, Walter Veit
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source