Results 161 to 170 of about 11,625,642 (355)

Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)

Nature Methods, 2006
M. Rust, Mark Bates, X. Zhuang
semanticscholar   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Transcriptome-Guided Imaging Genetic Analysis via a Novel Sparse CCA Algorithm

, 2017
Imaging genetics is an emerging field that studies the influence of genetic variation on brain structure and function. The major task is to examine the association between genetic markers such as single nucleotide polymorphisms (SNPs) and quantitative ...
Kwangsik Nho, Nho, Kwangsik, Saykin, Andrew, Danai Chasioti, Liu, Kefei, Yao, Xiaohui, Chasioti, Danai, Kefei Liu, Shen, Li, Risacher, Shannon, Andrew Saykin, Li Shen, null null, Yan, Jingwen, Jingwen Yan, Xiaohui Yao, Shannon Risacher   +16 more
core   +1 more source

The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository

Journal of digital imaging, 2013
K. W. Clark, Bruce A. Vendt, Kirk E. Smith, J. Freymann, J. Kirby, P. Koppel, S. Moore, Stanley R. Phillips, David R. Maffitt, Michael Pringle, Lawrence Tarbox, Fred W. Prior   +11 more
semanticscholar   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

International consensus on clinical use of presynaptic dopaminergic positron emission tomography imaging in parkinsonism.

Presynaptic dopaminergic positron emission tomography (PET) imaging serves as an essential tool in diagnosing and differentiating patients with suspected parkinsonism, including idiopathic Parkinson's disease (PD) and other neurodegenerative and non ...
Prior, J.O., Dou, X., Cahid Civelek, A., Zhou, R., Li, X., Wang, J., Carrio, I., Kang, K.W., Murakami, K., Tian, M., Watanabe, Y., Zhong, Y., Jin, C., Lu, J., Zuo, C., Zhang, H., Yu, C., Liu, F.   +17 more
core   +1 more source

MR diffusion tensor spectroscopy and imaging.

Biophysical Journal, 1994
P. Basser, J. Mattiello, D. LeBihan
semanticscholar   +1 more source