Results 91 to 100 of about 6,084,382 (354)

Tutorial on phantoms for photoacoustic imaging applications

Journal of Biomedical Optics
Photoacoustic imaging (PAI) is an emerging technology that holds high promise in a wide range of clinical applications, but standardized methods for system testing are lacking, impeding objective device performance evaluation, calibration, and inter-device comparisons.
Lina Hacker, James Joseph, Ledia Lilaj, Srirang Manohar, Aoife M. Ivory, Ran Tao, Sarah E. Bohndiek, null Members of IPASC   +7 more
openaire   +3 more sources

Automatic evaluation of the image quality of a mammographic phantom

Computer Methods and Programs in Biomedicine, 2004
In this work a method has been developed to analyse the digital image quality of a mammographic phantom by means of automatic process techniques. The techniques used for the digital image treatment are standard techniques as the image thresholding to detect objects, the regional growing for pixels pooling and the morphological operator application to ...
Mayo Nogueira, Patricia, Ródenas Escribá, Francisco De Asís, Verdú Martín, Gumersindo Jesús, Villaescusa, J.I, Campayo, Juan Manuel   +4 more
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Designing microarray phantoms for hyperspectral imaging validation

Biomedical Optics Express, 2012
The design and fabrication of custom-tailored microarrays for use as phantoms in the characterization of hyperspectral imaging systems is described. Corresponding analysis methods for biologically relevant samples are also discussed. An image-based phantom design was used to program a microarrayer robot to print prescribed mixtures of dyes onto ...
Ji Youn Lee, Maritoni Litorja, Daniel V. Samarov, Ralph Nossal, Matthew L. Clarke, David W. Allen, Jeeseong Hwang   +6 more
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Quantitative evaluation of an optimized Time of Flight Magnetic Resonance Imaging procedure using a phantom setup to simulate aqueous humor flow

Data in Brief, 2018
Preclinical Magnetic Resonance Imaging at high field strength offers the great advantage of combining anatomical information and very high resolution of down to 25 µm in mice and even higher resolutions in ex vivo settings.
Thomas Wecker, Christian van Oterendorp, Wilfried Reichardt   +2 more
doaj  

Design and Use of a Custom Phantom for Regular Tests of Radiography Apparatus: A Feasibility Study

Journal of Imaging
This study investigates the feasibility of employing an in-house-developed physical phantom dedicated to the weekly quality control testing of radiographic systems, performed by radiographers. For this purpose, a 3D phantom was fabricated, featuring test
Nikolay Dukov, Vanessa-Mery Valkova, Mariana Yordanova, Virginia Tsapaki, Kristina Bliznakova   +4 more
doaj   +1 more source

Experimental Breast Phantoms for Estimation of Breast Tumor Using Microwave Imaging Systems

IEEE Access, 2018
In this paper, the preparation and the measurement of a set of human breast phantoms for microwave breast imaging (MBI) as a method of tumor detection are presented.
Md Tarikul Islam, Md Samsuzzaman, Salehin Kibria, Mohammad Tariqul Islam   +3 more
doaj   +1 more source