Results 251 to 260 of about 6,300,829 (408)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

FEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source

Using the MIRD5 Mathematical Phantom to calculate the absorbed dose in organs in case of brain and chest CT scan

مجلة جامعة دمشق للعلوم الهندسية
Purpose: Simulate organs and calculate the absorbed dose in each organ for brain and chest CT scans.  Method and Materials: In this research; the mathematical phantom MIRD5 for adult men and women was used to calculate the absorbed dose in organs, in ...
عائشه العلي الجوار, Dr. Hani Amasha, prof. Nikola Abo Issa   +2 more
doaj  

Whole Process of Standardization of Diffusion-Weighted Imaging: Phantom Validation and Clinical Application According to the QIBA Profile. [PDF]

Diagnostics (Basel)
Choi SJ, Kim KW, Ko Y, Cho YC, Jang JS, Ahn H, Kim DW, Kim MY.   +7 more
europepmc   +1 more source

Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies. [PDF]

J Appl Clin Med Phys, 2017
Gerdekoohi SK, Vosoughi N, Tanha K, Assadi M, Ghafarian P, Rahmim A, Ay MR.   +6 more
europepmc   +1 more source

High field MREIT: setup and tissue phantom imaging at 11 T [PDF]

, 2006
Rosalind Sadleir, Samuel C. Grant, Sung-Uk Zhang, Suk Hoon Oh, Byung Il Lee, Eung Je Woo   +5 more
openalex   +1 more source

Model‐based mapping of fat unsaturation and chain length by chemical shift imaging—phantom validation and in vivo feasibility

Magnetic Resonance in Medicine, 2012
J. Berglund, H. Ahlström, J. Kullberg
semanticscholar   +1 more source