Results 61 to 70 of about 6,084,382 (354)

Linac-integrated on-board spectral-CT/CBCT imaging using a photon-counting detector: a Monte Carlo study

Frontiers in Physics, 2023
Purpose: To investigate the feasibility of dual-modal on-board spectral-CT/CBCT imaging using a CZT photon-counting detector mounted on a Linac by Monte Carlo simulations.Methods: In this proof-of-concept study, the Monte Carlo software platform of ...
Fengsong Ye, Hui Wang, Jianqiang Fang
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Multimodal phantom of liver tissue. [PDF]

PLoS ONE, 2013
Medical imaging plays an important role in patients' care and is continuously being used in managing health and disease. To obtain the maximum benefit from this rapidly developing technology, further research is needed.
Magdalena K Chmarra, Rune Hansen, Ronald Mårvik, Thomas Langø   +3 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

A novel 3D-printed head phantom with anatomically realistic geometry and continuously varying skull resistivity distribution for electrical impedance tomography

Scientific Reports, 2017
Phantom experiments are an important step for testing during the development of new hardware or imaging algorithms for head electrical impedance tomography (EIT) studies.
Jie Zhang, Bin Yang, Haoting Li, Feng Fu, Xuetao Shi, Xiuzhen Dong, Meng Dai   +6 more
doaj   +1 more source

Solid switchable phantom for diffuse optical imaging [PDF]

SPIE Proceedings, 2015
We propose a simple and reliable solid phantom for mimicking localized absorption changes within a diffusive medium. The phantom is based on the Equivalence Relation stating that any realistic absorption inhomogeneity can be mimicked by a totally absorbing sphere of adequate volume.
PIFFERI, ANTONIO GIOVANNI, TORRICELLI, ALESSANDRO, CUBEDDU, RINALDO, QUARTO, GIOVANNA, RE, REBECCA, KONUGOLU VENKATA SEKAR, SANATHANA, SPINELLI, LORENZO, FARINA, ANDREA, Martelli, Fabrizio, Wabnitz, Heidrun   +9 more
openaire   +3 more sources

Toward Precision and Reproducibility of Diffusion Tensor Imaging: A Multicenter Diffusion Phantom and Traveling Volunteer Study

American Journal of Neuroradiology, 2016
BACKGROUND AND PURPOSE: Precision medicine is an approach to disease diagnosis, treatment, and prevention that relies on quantitative biomarkers that minimize the variability of individual patient measurements.
E. Palacios, A.J. Martin, M. Boss, F. Ezekiel, Y. Chang, E. Yuh, M. Vassar, David M Schnyer, C.L. MacDonald, K. Crawford, A. Irimia, A. Toga, P. Mukherjee   +12 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Triggered kV Imaging During Spine SBRT for Intrafraction Motion Management

Technology in Cancer Research & Treatment, 2021
Purpose: To monitor intrafraction motion during spine stereotactic body radiotherapy(SBRT) treatment delivery with readily available technology, we implemented triggered kV imaging using the on-board imager(OBI) of a modern medical linear accelerator ...
Jihye Koo, Louis Nardella, Michael Degnan, Jacqueline Andreozzi, Hsiang-hsuan M. Yu, Jose Penagaricano, Peter A. S. Johnstone, Daniel Oliver, Kamran Ahmed, Stephen A. Rosenberg, Evan Wuthrick, Roberto Diaz, Vladimir Feygelman, Kujtim Latifi, Eduardo G. Moros, Gage Redler   +15 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source