Results 81 to 90 of about 6,084,382 (354)

Requirement analysis in medical phantom development: a survey tool approach with an illustrative example of a multimodal deformable pelvic phantom

Frontiers in Physics
IntroductionMedical phantoms play a crucial role in medical imaging and therapy. However, the successful development of these phantoms heavily relies on a comprehensive understanding of the requirements specific to each application.MethodsIn this paper ...
Marie Wegner, Marie Wegner, Jonte Schmiech, Eve Sobirey, Dieter Krause, Elisabetta Gargioni   +5 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Stereoscopic Near-Infrared Fluorescence Imaging: A Proof of Concept Toward Real-Time Depth Perception in Surgical Robotics

Frontiers in Robotics and AI, 2019
The increasing use of surgical robotics has provoked the necessity for new medical imaging methods. Many assistive surgical robotic systems influence the surgeon's movements based on a model of constraints and boundaries driven by anatomy.
Maxwell J. Munford, Ferdinando Rodriguez y Baena, Stuart Bowyer   +2 more
doaj   +1 more source

Tissue-like phantoms for quantitative birefringence imaging

Biomedical Optics Express, 2017
Birefringence imaging, including polarization sensitive optical coherence tomography (PS-OCT), can provide valuable insight into the microscopic structure and organization of many biological tissues. In this paper, we report on a method to fabricate tissue-like birefringence phantoms for such imaging modalities.
Liu, Xinyu, Beaudette, Kathy, Wang, Xianghong, Liu, Linbo, Bouma, Brett E., Villiger, Martin   +5 more
openaire   +5 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Metamaterial Loaded Nine High Gain Vivaldi Antennas Array for Microwave Breast Imaging Application

IEEE Access, 2020
In this article, a metamaterial loaded high gain nine antennas based microwave breast imaging system has presented to detect an unwanted tumour in the breast phantom.
Md Tarikul Islam, Mohammad Tariqul Islam, Md Samsuzzaman, Haslina Arshad, Hatem Rmili   +4 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Hybrid organosilicon/polyol phantom for photoacoustic imaging

Biomedical Optics Express, 2019
The rapid development of hardware and software for photoacoustic technologies is urging the establishment of dedicated tools for standardization and performance assessment. In particular, the fabrication of anatomical phantoms for photoacoustic imaging remains an open question, as current solutions have not yet gained unanimous support.
Ratto Fulvio, Cavigli Lucia, Borri Claudia, Centi Sonia, Magni Giada, Mazzoni Marina, Pini Roberto   +6 more
openaire   +5 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The effect of spatial resolution on the reproducibility of diffusion imaging when controlled signal to noise ratio

Biomedical Journal, 2019
Background: The purpose of the study is to evaluate the reproducibility and repeatability of the compartmental diffusion measurement. Methods: Two identical whipping cream phantoms and two healthy Sprague–Dawley rats were scanned on a 7T MR scanner, each
Yao-Liang Chen, Yu-Jen Lin, Sung-Han Lin, Chih-Chien Tsai, Yu-Chun Lin, Jur-Shan Cheng, Jiun-Jie Wang   +6 more
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