Results 151 to 160 of about 106,545 (283)
Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors [PDF]
, 2002 George D. Demetri +20 more
openalex +1 more source
Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians
Diabetes, Obesity and Metabolism, EarlyView.Abstract Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells by autoreactive T lymphocytes, leading to insulin deficiency and lifelong insulin dependence. It develops in genetically predisposed individuals, triggered by environmental or immunological factors.
François‐Xavier Mauvais +1 more
wiley +1 more source
Cardiac tamponade associated with imatinib mesylate therapy of chronic myelogenous leukemia [PDF]
, 2002 James C. Barton +4 more
openalex +1 more source
Treatment‐Free Remission in Chronic Myeloid Leukemia: Revisiting the “W” Questions
European Journal of Haematology, EarlyView.ABSTRACT Chronic myeloid leukemia (CML) has undergone a transformation from a fatal disease to a chronic, manageable condition with the advent of tyrosine kinase inhibitors (TKIs), particularly imatinib. This shift has significantly improved survival rates, and for some patients, achieving deep molecular response (DMR) has made treatment‐free remission
Antonella Bruzzese +9 more
wiley +1 more source
ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma
The FEBS Journal, EarlyView.KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe +12 more
wiley +1 more source
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]
, 2018 Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J +18 more
core +1 more source
Myelodysplastic subclones in chronic myeloid leukemia: implications for imatinib mesylate therapy [PDF]
, 2002 Stuart L. Goldberg +5 more
openalex +1 more source
Journal of the European Academy of Dermatology and Venereology, EarlyView.This study identifies interferons as key mediators in lichenoid chronic GVHD pathogenesis, along with Th2 and Th17 involvement. It particularly highlights the role of Type I interferon, showing that early anti‐IFNAR1 treatment reduces skin inflammation in a murine model of chronic cutaneous GVHD.
Chloé Grolleau +11 more
wiley +1 more source
Comprehensive management of vulvovaginal cancers
CA: A Cancer Journal for Clinicians, EarlyView.Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues +5 more
wiley +1 more source